Biology and therapeutic potential of mesenchymal stem cell‐derived exosomes

Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC‐based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion...

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Bibliographic Details
Published inCancer science Vol. 111; no. 9; pp. 3100 - 3110
Main Authors Xunian, Zhou, Kalluri, Raghu
Format Journal Article
LanguageEnglish
Published Tokyo John Wiley & Sons, Inc 01.09.2020
John Wiley and Sons Inc
Subjects
Biosynthesis
Cancer
Cell differentiation
Cell signaling
Deoxyribonucleic acid
DNA
Exosomes
Heat shock proteins
Hypoxia
immunomodulation
Inflammation
Kinases
Ligands
Lipids
Membranes
Mesenchymal stem cells
Mitochondrial DNA
MSC‐derived exosomes
Paracrine signalling
Plasma
Review
Ribonucleic acid
RNA
Senescence
Stem cells
Stromal cells
Transfer RNA
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Summary:Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC‐based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC‐derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC‐derived exosomes in cancer, with a focus on clinical translation opportunities. The biology and therapeutic potential of mesenchymal stem cell‐derived exosomes.
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ISSN:1347-9032
1349-7006
1349-7006
DOI:10.1111/cas.14563