Epigenomic dynamics of early Xenopus Embryos

How the embryonic genome regulates accessibility to transcription factors is one of the major questions in understanding the spatial and temporal dynamics of gene expression during embryogenesis. Epigenomic analyses of embryonic chromatin provide molecular insights into cell‐specific gene activities...

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Bibliographic Details
Published inDevelopment, growth & differentiation Vol. 64; no. 9; pp. 508 - 516
Main Authors Zhou, Jeff Jiajing, Cho, Ken W. Y.
Format Journal Article
LanguageEnglish
Published Japan Wiley Subscription Services, Inc 01.12.2022
Subjects
Animals
Chromatin
Chromatin - metabolism
Embryogenesis
Embryonic Development - genetics
Epigenomics
Gene expression
Gene Expression Regulation, Developmental
Transcription factors
Xenopus
Xenopus laevis - genetics
Zygote - metabolism
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Summary:How the embryonic genome regulates accessibility to transcription factors is one of the major questions in understanding the spatial and temporal dynamics of gene expression during embryogenesis. Epigenomic analyses of embryonic chromatin provide molecular insights into cell‐specific gene activities and genomic architectures. In recent years, significant advances have been made to elucidate the dynamic changes behind the activation of the zygotic genome in various model organisms. Here we provide an overview of the recent epigenomic studies pertaining to early Xenopus development.
Bibliography:Funding information
National Institutes of Health, Grant/Award Numbers: R01GM126395, R35GM139617; National Science Foundation, Grant/Award Number: 1755214
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ObjectType-Review-1
ISSN:0012-1592
1440-169X
DOI:10.1111/dgd.12813