Copper-Catalyzed Synthesis of Quinazolines in Water Starting from o-Bromobenzylbromides and Benzamidines

Water makes it possible: The Cu2O‐catalyzed reaction between easily available o‐bromobenzylbromides and benzamidines by using Cs2CO3 as the base and N,N′‐dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields rang...

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Bibliographic Details
Published inChemistry : a European journal Vol. 18; no. 29; pp. 8882 - 8885
Main Authors Malakar, Chandi C., Baskakova, Alevtina, Conrad, Jürgen, Beifuss, Uwe
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 16.07.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Additives
Benzamidines - chemistry
Benzyl Compounds - chemistry
Catalysis
Chemistry
Chemistry, Multidisciplinary
copper
Copper - chemistry
domino reactions
Ethylenediamines - chemistry
heterocycles
Molecular Structure
N-arylation
Physical Sciences
Quinazolines - chemical synthesis
Quinazolines - chemistry
Science & Technology
Solvents
Synthesis
Water
water chemistry
PALLADIUM
N-arylation
domino reactions
heterocycles
COUPLING REACTIONS
copper
ARYL
INHIBITORS
water chemistry
DERIVATIVES
EFFICIENT
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Summary:Water makes it possible: The Cu2O‐catalyzed reaction between easily available o‐bromobenzylbromides and benzamidines by using Cs2CO3 as the base and N,N′‐dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme).
Bibliography:istex:B704BF72C4D4BA451CA262B9AC7B6639DB974CF4
ArticleID:CHEM201200583
ark:/67375/WNG-7P6THRDT-D
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201200583