Copper-Catalyzed Synthesis of Quinazolines in Water Starting from o-Bromobenzylbromides and Benzamidines
Water makes it possible: The Cu2O‐catalyzed reaction between easily available o‐bromobenzylbromides and benzamidines by using Cs2CO3 as the base and N,N′‐dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields rang...
Saved in:
Published in | Chemistry : a European journal Vol. 18; no. 29; pp. 8882 - 8885 |
---|---|
Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
16.07.2012
WILEY‐VCH Verlag Wiley Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Water makes it possible: The Cu2O‐catalyzed reaction between easily available o‐bromobenzylbromides and benzamidines by using Cs2CO3 as the base and N,N′‐dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme). |
---|---|
Bibliography: | istex:B704BF72C4D4BA451CA262B9AC7B6639DB974CF4 ArticleID:CHEM201200583 ark:/67375/WNG-7P6THRDT-D ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0947-6539 1521-3765 |
DOI: | 10.1002/chem.201200583 |