Pancreatic adenosquamous carcinoma: A population level analysis of epidemiological trends and prognosis

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 8; pp. 9926 - 9936
• Main Authors: Huang, Zhihao, Wang, Jiakun, Zhang, Rongguiyi, He, Aoxiao, Luo, Shuaiwu, Wu, Rongshou, Xiong, Jianghui, Li, Min, Jin, Tao, Li, Enliang, Wu, Linquan, Liao, Wenjun
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc; Wiley
• Subjects: Adenocarcinoma; Adenomatous polyposis coli; Adenosquamous; annual percent change; Carcinoma, Adenosquamous - epidemiology; Carcinoma, Adenosquamous - pathology; Classification; Disease; epidemiological trends; Epidemiology; Humans; Lymph nodes; Males; Medical prognosis; Mortality; Nomograms; Pancreas; pancreatic adenosquamous carcinoma; Pancreatic cancer; Pancreatic carcinoma; Pancreatic Neoplasms; Pancreatic Neoplasms - epidemiology; Patients; Population; Prognosis; SEER; SEER Program; Squamous cell carcinoma; Survival; Trends; Tumors; United States > US; epidemiological trends; annual percent change; SEER; pancreatic adenosquamous carcinoma; prognosis
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.5700

Background The incidence and mortality of pancreatic adenosquamous carcinoma (PASC) have received little attention. The goal of our study was to explore the overall epidemiological trend of PASC at the population level. Methods The Surveillance, Epidemiology, and End Results database was used to collect the incidence, incidence‐based (IB) mortality, and patient details for PASC from 2000 to 2017. The Joinpoint regression tool was used to examine the trends in incidence and IB mortality. The Kaplan–Meier approach was used for survival analysis. Univariate and multivariate Cox regression analyses were used to determine the independent prognostic factors. Results We included 815 patients with PASC in the study. The incidence of PASC continuously increased from 2000 to 2017, with an annual percentage change (APC) of 3.9% (95% CI: 2.2%–5.7%, p < 0.05). IB mortality also increased continuously, with an APC of 5.0% (95% CI: 2.5%–7.6%, p < 0.05). Multivariate Cox regression analysis revealed that age, treatment, regional lymph node involvement, and tumor size were independent prognostic factors. Nomograms were created for PASC to predict 1‐ and 2‐year survival probabilities, respectively. Conclusions The incidence and IB mortality of PASC had a sustained and rapid increase, indicating that the preventive and treatment measures for PASC were not ideal. We must identify the significance of this condition as soon as possible, and commit greater attention and resources to PASC research. The incidence and IB mortality of PASC have been steadily increasing in recent years, manifesting that the preventive and treatment measures of PASC are not ideal. Therefore, we must identify the significance of this condition as soon as possible and commit greater attention and resources to it. This can help us further understand PASC and develop more targeted and standardized preventive and therapeutic measures.