Osteocalcin-A Versatile Bone-Derived Hormone

Bone has long been regarded as a static organ, simply providing protection and support. However, this mindset has changed radically in recent years and bone is becoming increasingly recognized for its endocrine function of secreting several hormones, thereby controlling various physiological pathway...

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Published inFrontiers in endocrinology (Lausanne) Vol. 9; p. 794
Main Authors Moser, Sarah C, van der Eerden, Bram C J
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 10.01.2019
Subjects
bone
cognition
Endocrinology
energy metabolism
exercise
osteoblasts
osteocalcin
cognition
fertility
exercise
osteocalcin
bone
osteoblasts
endocrine regulation
energy metabolism
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Summary:Bone has long been regarded as a static organ, simply providing protection and support. However, this mindset has changed radically in recent years and bone is becoming increasingly recognized for its endocrine function of secreting several hormones, thereby controlling various physiological pathways. One of the factors released by the skeleton is osteocalcin. Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility. The aim of this review is to provide an overview of the currently known roles of osteocalcin and their underlying mechanisms. At present, one of the major goals in this field is translating basic research into therapeutic applications, therefore ongoing efforts to bring these findings to the clinics will also be discussed.
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Reviewed by: Graziana Colaianni, Università degli Studi di Bari, Italy; Colin Farquharson, University of Edinburgh, United Kingdom
Edited by: Gudrun Stenbeck, Brunel University London, United Kingdom
This article was submitted to Bone Research, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2018.00794