Origins of the mobile gene cassettes found in integrons

Many of the acquired antibiotic resistance genes found in enterobacteria and pseudomonads are part of small mobile elements known as gene cassettes, and other genes are also likely to be found in cassettes. The origins of the genes and the recombination sites that make up cassettes are not known, bu...

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Bibliographic Details
Published inTrends in microbiology (Regular ed.) Vol. 5; no. 10; pp. 389 - 394
Main Authors Recchia, Gavin D., Hall, Ruth M.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.1997
Subjects
DNA Transposable Elements - genetics
Drug Resistance, Microbial - genetics
Genes, Bacterial
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Summary:Many of the acquired antibiotic resistance genes found in enterobacteria and pseudomonads are part of small mobile elements known as gene cassettes, and other genes are also likely to be found in cassettes. The origins of the genes and the recombination sites that make up cassettes are not known, but recent analyses of available data suggest that cassettes may be ancient structures, and some hypotheses for how they are formed can now be examined.
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ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(97)01123-2