Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorder

• Published in: Acta pharmacologica Sinica Vol. 35; no. 1; pp. 24 - 32
• Main Authors: Huang, Zhong-lin, Liu, Rui, Bai, Xiao-yu, Zhao, Gang, Song, Jun-ke, Wu, Song, Du, Guan-hua
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2014; Nature Publishing Group
• Subjects: Adenosine - administration & dosage; Adenosine - analogs & derivatives; Adenosine - chemistry; Animals; Bax; Bcl-2; Biomedical and Life Sciences; Biomedicine; Disease Models, Animal; Hippocampus - drug effects; Hippocampus - metabolism; Hippocampus - pathology; Immunology; Internal Medicine; Male; Medical Microbiology; Mice; Neuroprotective Agents - administration & dosage; Neuroprotective Agents - chemistry; Original; original-article; Pharmacology/Toxicology; Stress Disorders, Post-Traumatic - metabolism; Stress Disorders, Post-Traumatic - pathology; Stress Disorders, Post-Traumatic - prevention & control; Vaccine; 保护作用; 创伤; 小鼠模型; 应激; 神经细胞凋亡; 腺苷; 衍生物; adenosine; memory deficits; Bcl-2; anxiety; paroxetine; hippocampus; AMG-1; Bax; WS0701; apoptosis; posttraumatic stress disorder; fear

Aim： To investigate the effects of the novel N6-substituted adenosine derivative {（2R,3S,4R,5R）-3,4-dihydroxy-5-[6-[（4-hydroxy-3-methoxybenzyl）amino]-9H-purin-9-yl]tetrahydrofuran-2-yl} methyl decanoate （WS0701） on stress-induced excessive fear, anxiety, and cognitive deficits in a mouse model of po...