Diagnosis and definition of treatment-resistant depression

Treatment-resistant depression (TRD) typically refers to inadequate response to at least one antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinical practice, with up to 50% to 60% of the patients not achieving adequate response following antidepressant...

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Bibliographic Details
Published inBiological psychiatry (1969) Vol. 53; no. 8; pp. 649 - 659
Main Author Fava, Maurizio
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.04.2003
Elsevier Science
Subjects
Adult and adolescent clinical studies
Antidepressive Agents - therapeutic use
Biological and medical sciences
definition
Depression
Depressive Disorder, Major - diagnosis
Depressive Disorder, Major - psychology
Depressive Disorder, Major - therapy
diagnosis
Drug Resistance
Electroconvulsive Therapy
Humans
Medical sciences
Mood disorders
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychotherapy
resistance
Terminology as Topic
treatment
treatment
Depression
diagnosis
definition
resistance
Mood disorder
Performance evaluation
Human
Treatment resistance
Questionnaire
Treatment efficiency
Definition
Chemotherapy
Treatment
Antidepressant agent
Diagnosis
Technique
Predictive factor
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Summary:Treatment-resistant depression (TRD) typically refers to inadequate response to at least one antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinical practice, with up to 50% to 60% of the patients not achieving adequate response following antidepressant treatment. A diagnostic re-evaluation is essential to the proper management of these patients. In particular, the potential role of several contributing factors, such as medical and psychiatric comorbidity, needs to be taken into account. An accurate and systematic assessment of TRD is a challenge to both clinicians and researchers, with the use of clinician-rated or self-rated instruments being perhaps quite helpful. It is apparent that there may be varying degrees of treatment resistance. Some staging methods to assess levels of treatment resistance in depression are being developed, but need to be tested empirically.
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ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(03)00231-2