The development of bioartificial nerve grafts for peripheral-nerve regeneration

This article describes recent, significant scientific advances leading to the development of the bioartificial nerve graft. Schwann cells, which play an active role in the repair and function of peripheral nerves, are used to seed a synthetic, often resorbable conduit, which is then used to bridge a...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 16; no. 4; pp. 163 - 168
Main Authors Heath, Carole A, Rutkowski, Gregory E
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.04.1998
Elsevier Science
Subjects
Animals
Artificial Organs
bioartificial graft
Biocompatible Materials
Biological and medical sciences
Biotechnology
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Nerve Regeneration
peripheral nervous system
Peripheral Nervous System - physiology
Schwann cells
Vertebrates: nervous system and sense organs
nerve regeneration
peripheral nervous system
bioartificial graft
Schwann cells
Peripheral nervous system
Peripheral nerve
Regeneration
Schwann cell
Graft
Absorbable
Biomaterial
Models
Review
Technique
Repair
Silicone elastomer
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Summary:This article describes recent, significant scientific advances leading to the development of the bioartificial nerve graft. Schwann cells, which play an active role in the repair and function of peripheral nerves, are used to seed a synthetic, often resorbable conduit, which is then used to bridge and repair nerve gaps caused by injury or disease. By enhancing the rate and extent of regeneration, the bioartificial nerve graft holds great promise for improving recovery in the peripheral (and central) nervous system.
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ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(97)01165-7