Is Hypovitaminosis D a Risk Factor for Heart Failure?

• Published in: Life (Basel, Switzerland) Vol. 13; no. 2; p. 372
• Main Authors: Hagău, Asmaa Carla, Pușcaș, Amalia, Togănel, Rodica, Muntean, Iolanda
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2023; MDPI
• Subjects: adults; Alfacalcidol; Calcifediol; Calciferol; Cardiac patients; Cardiomyocytes; cardiovascular; Cardiovascular diseases; children; Clinical medicine; Clinical trials; Complications and side effects; Congestive heart failure; Development and progression; Dietary supplements; Failure analysis; Gene expression; Health aspects; Heart failure; Hypertension; Kidney diseases; Medical research; Medicine, Experimental; Morbidity; Mortality; Pediatrics; Risk factors; Skin; Systematic Review; Vitamin D; Vitamin D deficiency; Vitamin deficiency; Romania; Vitamin D deficiency; heart failure; risk factors; cardiovascular; children; adults
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life13020372

Several studies in recent years have shown the association between vitamin D levels and heart failure. Vitamin D deficiency is related to increased cardiovascular morbidity and mortality, with a higher risk of developing heart failure. In this systematic review, we aimed to assess recent studies that analyzed vitamin D deficiency and heart failure in adult and pediatric populations. (2) Methods: We conducted a systematic search for studies published in the following databases: PubMed and Scopus from January 2012 to October 2022. (3) Results: Most observational studies that were included found a significant association between hypovitaminosis D and heart failure. However, the beneficial role of vitamin D supplementation is still controversial due to the lack of randomized controlled trials. (4) Conclusions: Vitamin D may play an important role as a cardiovascular marker in heart failure patients. More well-designed studies are needed to investigate the relationship between vitamin D and heart failure and to determine if vitamin D supplementation could improve long-term outcomes.