Differential Role for Transcription Factor Oct4 Nucleocytoplasmic Dynamics in Somatic Cell Reprogramming and Self-renewal of Embryonic Stem Cells

• Published in: The Journal of biological chemistry Vol. 288; no. 21; pp. 15085 - 15097
• Main Authors: Oka, Masahiro, Moriyama, Tetsuji, Asally, Munehiro, Kawakami, Koichi, Yoneda, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 24.05.2013; American Society for Biochemistry and Molecular Biology
• Subjects: Active Transport, Cell Nucleus - physiology; Animals; Cell Biology; Cell Differentiation - physiology; Cell Nucleus - genetics; Cell Nucleus - metabolism; Differentiation; Embryonic Stem Cell; Embryonic Stem Cells - cytology; Embryonic Stem Cells - metabolism; Mice; NIH 3T3 Cells; Nuclear Transport; Nucleocytoplasmic Shuttling; Oct4; Octamer Transcription Factor-3 - genetics; Octamer Transcription Factor-3 - metabolism; Reprogramming; Transcription Factors; Nucleocytoplasmic Shuttling; Oct4; Reprogramming; Transcription Factors; Differentiation; Nuclear Transport; Embryonic Stem Cell

Oct4 is a member of the POU family of transcription factors and plays a critical role in both maintenance of the undifferentiated state of embryonic stem (ES) cells and in the reprogramming of somatic cells to induced pluripotent stem cells. Oct4 is imported into the nucleus where it functions as a...