Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerat...

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Published inScience (American Association for the Advancement of Science) Vol. 366; no. 6465; pp. 628 - 631
Main Authors Fultz, Nina E., Bonmassar, Giorgio, Setsompop, Kawin, Stickgold, Robert A., Rosen, Bruce R., Polimeni, Jonathan R., Lewis, Laura D.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 01.11.2019
The American Association for the Advancement of Science
Subjects
Adult
Blood volume
Brain
Brain - blood supply
Brain - physiology
Brain mapping
Brain Waves - physiology
Cerebrospinal fluid
Cerebrospinal Fluid - physiology
Cerebrovascular Circulation
Cognition
Computational fluid dynamics
Consolidation
Delta Rhythm
EEG
Electroencephalography
Eye movements
Female
Fluid dynamics
Functional magnetic resonance imaging
Hemodynamics
Human motion
Humans
Hydrodynamics
Inflow
Magnetic Resonance Imaging
Maintenance
Male
Medical imaging
Memory
Metabolic wastes
Metabolism
Motor Reactions
Neuroimaging
Neurology
NREM sleep
Oscillations
REM sleep
Sleep
Sleep - physiology
Young Adult
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Summary:Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) clears metabolic waste products from the brain. Whether these two processes are related is not known. We used accelerated neuroimaging to measure physiological and neural dynamics in the human brain. We discovered a coherent pattern of oscillating electrophysiological, hemodynamic, and CSF dynamics that appears during non–rapid eye movement sleep. Neural slow waves are followed by hemodynamic oscillations, which in turn are coupled to CSF flow. These results demonstrate that the sleeping brain exhibits waves of CSF flow on a macroscopic scale, and these CSF dynamics are interlinked with neural and hemodynamic rhythms.
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Author contributions: All authors contributed to design; L.D.L. and N.F. collected and analyzed data; L.D.L. wrote the manuscript; all authors edited the manuscript.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.aax5440