A probiotics-containing biscuit modulates the intestinal microbiota in the elderly

• Published in: The Journal of nutrition, health & aging Vol. 17; no. 2; pp. 166 - 172
• Main Authors: Rampelli, S., Candela, M., Severgnini, M., Biagi, E., Turroni, S., Roselli, M., Carnevali, P., Donini, L., Brigidi, P.
• Format: Journal Article
• Language: English
• Published: Paris Elsevier Masson SAS 01.02.2013; Springer-Verlag; Serdi; Springer; Springer Nature B.V
• Subjects: Age; Aged; Aged, 80 and over; Aging; Antibiosis; Antibiosis - drug effects; Antibiotics; Bacteria; Bacteria - drug effects; Bifidobacterium longum; Biological and medical sciences; Campylobacter; Clostridium difficile; Clostridium perfringens; Double-Blind Method; drug effects; dysbioses; elderly; Enterococcus faecium; Feeding. Feeding behavior; Female; Food science; functional foods; Functional foods & nutraceuticals; Fundamental and applied biological sciences. Psychology; Geriatrics/Gerontology; Humans; Immune system; inflammaging; Intestinal Diseases; Intestinal Diseases - microbiology; Intestinal Diseases - prevention & control; Intestinal microbiota; intestinal microorganisms; Intestines; Intestines - microbiology; Italy; Lactobacillus helveticus; Male; Medicine; Medicine & Public Health; men; Metagenome; Microarray Analysis; microarray technology; microbiology; Microbiota; Neurosciences; Nutrition; Nutrition research; Older people; Pathogens; Phylogenetics; phylogeny; Physiology; prevention & control; Primary Care Medicine; Probiotics; Probiotics - therapeutic use; Quality of Life Research; Taxonomy; therapeutic use; Vertebrates: anatomy and physiology, studies on body, several organs or systems; volunteers; women; Italy; inflammaging; dysbioses; aging; Intestinal microbiota; probiotics; Human; Probiotic; Digestive system; Ageing; Gut; Metabolic diseases; Elderly
• ISSN: 1279-7707; 1760-4788; 1760-4788
• DOI: 10.1007/s12603-012-0372-x

Evaluation of the impact of a biscuit containing the probiotics Bifidobacterium longum Bar33 and Lactobacillus helveticus Barl3 on the intestinal microbiota in the elderly. Randomized double-blind placebo-controlled trial. Thirty-two elderly volunteers living in Italy. The group was composed of 19 women and 13 men aged between 71 and 88 years (mean 76). Subjects were randomized in two groups consuming one dose of the probiotics-containing biscuit or placebo once a day for 30 days. For each subject the intestinal microbiota was characterized using the phylogenetic microarray platform HTF-Microbi. Array before and after intervention. Our data demonstrated that one-month consumption of a probiotics-containing biscuit was effective in redressing some of the age-related dysbioses of the intestinal microbiota. In particular, the probiotic treatment reverted the age-related increase of the opportunistic pathogens Clostridium cluster XI, Clostridium difficile, Clostridium perfringens, Enterococcus faecium and the enteropathogenic genus Campylobacter. The present study opens the way to the development of elderly-tailored probiotic-based functional foods to counteract the age-related dysbioses of the intestinal microbiota.