The Regulation of Hemostasis: The Protein C System

• Published in: The New England journal of medicine Vol. 314; no. 20; pp. 1298 - 1304
• Main Authors: Clouse, Lawrence H, Comp, Philip C
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 15.05.1986
• Subjects: Adult; Anticoagulants; Biological and medical sciences; Blood and lymphatic vessels; Blood Coagulation Disorders - etiology; Blood Coagulation Factors - physiology; Blood Proteins - isolation & purification; Blood Proteins - physiology; Cardiology. Vascular system; Coagulation; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Fibrinolysis; Glycoproteins - deficiency; Glycoproteins - physiology; Hemostasis; Humans; Infant, Newborn; Leukemia - blood; Male; Medical sciences; Protein C; Protein C Inhibitor; Protein S; Proteins; Receptors, Cell Surface - isolation & purification; Receptors, Cell Surface - physiology; Receptors, Thrombin; Studies; Thromboembolism - etiology; Thrombosis; Vitamin K - physiology; Human; Blood coagulation; Venous disease of the limb; Deficiency; Cardiovascular disease; Protein C; Hemopathy; Recurrent; Vein; Thrombosis; Coagulopathy
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM198605153142006

We speak very frequently of the normal clotting time. In a glass tube?... Glass tubes have held the center of the stage for quite a long time but the process of clotting is now observed in plastic vessels and a considerably longer period of time is required than when glass is used... If the same blood were kept outside the body in a test tube made from a vein or artery it would take a very long time to clot. — Charles H. Best, 1948 1 EXTENSIVE investigation into the mechanisms of blood clotting has yielded substantial insights into the process . . .