Improvement of Hyperglycemia and Sexual Dysfunction in Diabetic Female Rats by an Artificial Endocrine Pancreas Developed from Mouse β Cells

• Published in: Experimental Animals Vol. 59; no. 4; pp. 515 - 519
• Main Authors: HASHIMOTO, Haruo, MORITANI, Naoki, TERADA, Misao, KROMKHUN, Pudcharaporn, FUNGFUAUG, Wirasak, NAKADA, Tomoaki, YOKOSUKA, Makoto, SAITO, Toru R.
• Format: Journal Article
• Language: English
• Published: Japan Japanese Association for Laboratory Animal Science 2010
• Subjects: Animals; bioartificial endocrine pancreas; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Experimental - surgery; diabetic rats; Female; Hyperglycemia - surgery; Insulin-Secreting Cells; Islets of Langerhans Transplantation - methods; Mice; Ovariectomy; Pancreas, Artificial; Posture; Rats; Sexual Behavior, Animal - physiology; Sexual Dysfunction, Physiological - physiopathology; Sexual Dysfunction, Physiological - surgery; streptozotocin; Transplantation, Heterologous
• ISSN: 1341-1357; 1881-7122
• DOI: 10.1538/expanim.59.515

We investigated the effects of a bioartificial endocrine pancreas (Bio-AEP) produced by mouse β cells on sexual dysfunction of streptozotocin (STZ)-induced diabetic female rats. Female rats were administered STZ (60 mg/kg BW, i.v.) at the age of 10 weeks and transplanted with a Bio-AEP including mouse β cells at the age of 14 weeks (STZ+Bio-AEP group). Lordosis and proceptive sexual behavior of female rats were observed. The results showed that after the Bio-AEP transplant blood glucose recovered from 380–450 mg/dl induced by streptozotocin to 140–230 mg/dl and suppressed lordosis and proceptive behavior also recovered. These results suggest that it is possible to reverse sexual dysfunction by continuous administration of mouse insulin.