The anaphase-promoting complex: a key factor in the regulation of cell cycle

• Published in: Oncogene Vol. 24; no. 3; pp. 314 - 325
• Main Authors: CASTRO, Anna, BERNIS, Cyril, VIGNERON, Suzanne, LABBE, Jean-Claude, LORCA, Thierry
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing 13.01.2005; Nature Publishing Group
• Subjects: Anaphase - physiology; Anaphase-Promoting Complex-Cyclosome; Animals; Biological and medical sciences; Cell cycle; Cell Cycle - physiology; Cell Division; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; DNA Replication; Enzymes; Fundamental and applied biological sciences. Psychology; Homeostasis; Mitosis - physiology; Molecular and cellular biology; Proteins; Ubiquitin - metabolism; Ubiquitin-Conjugating Enzymes - physiology; Ubiquitin-Protein Ligase Complexes - physiology; Regulation(control); cdc20; Carbon-nitrogen ligases; APC; cdh1; Enzyme; Ligases; Mitosis; Proteolysis; Cell cycle; Carcinogenesis; Ubiquitin-protein ligase
• ISSN: 0950-9232; 1476-5594
• DOI: 10.1038/sj.onc.1207973

Events controlling cell division are governed by the degradation of different regulatory proteins by the ubiquitin-dependent pathway. In this pathway, the attachment of a polyubiquitin chain to a substrate by an ubiquitin-ligase targets this substrate for degradation by the 26S proteasome. Two different ubiquitin ligases play an important role in the cell cycle: the SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC). In this review, we describe the present knowledge about the APC. We pay particular attention to the latest results concerning APC structure, APC regulation and substrate recognition, and we discuss the implication of these findings in the understanding the APC function.