Correlation of Ionized Magnesium with the Parameters of Oxidative Stress as Potential Biomarkers in Patients with Anxiety and Depression: A Pilot Study

• Published in: Dose-response Vol. 20; no. 3; pp. 155932582211167 - 15593258221116741
• Main Authors: Opanković, Ana, Milovanović, Srđan, Radosavljević, Branimir, Čavić, Milena, Besu Žižak, Irina, Bukumirić, Zoran, Latas, Milan, Medić, Branislava, Vučković, Sonja, Srebro, Dragana, Savić Vujović, Katarina
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.07.2022; SAGE PUBLICATIONS, INC; SAGE Publishing
• Subjects: Anxiety; Biomarkers; Inflammatory Parameters as Early Biomarkers in Prediction and Monitoring of Therapeutic Effects in Preclinical and Clinical Studies; Mental depression; Oxidative stress; Somatoform disorders; anxiety; depression; inflammation; oxidative stress; ionized magnesium
• ISSN: 1559-3258; 1559-3258
• DOI: 10.1177/15593258221116741

Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the only active form of Mg. The concentration of ionized Mg could be a potentially novel biomarker for anxiety and depression. Aim The aim of this study was to assess the serum concentration of ionized Mg and its correlation with biomarkers of oxidative stress and inflammation in patients with anxiety and depression. Methods In this study included 93 respondents were divided into 3 groups: C (control group—18 respondents); A (patients with anxiety disorder, dissociative/conversion disorders and somatoform disorders—36 patients); D (patients with depression—39 patients). Clinical diagnosis was based on ICD-10 criteria. Blood samples were used for standard laboratory analysis, ionized Mg analysis, oxidative stress, and inflammatory parameters. Results Statistical significance was recorded between healthy volunteers and patients (anxiety/depression) in ionized Mg values. In anxious patients, malondialdehyde (MDA) had a positive correlation between the parameters of oxidative stress with ionized Mg. In depressive patients, MDA had a positive correlation, and glutathione peroxidase 1 (GPX1) a negative correlation with the concentration of ionized Mg. Conclusion Ionized Mg and its correlation with parameters of oxidative stress could be potential biomarkers in anxious and depressive patients.