Tetraazaindenes Derived from Dihydropyrazines with DNA Strand-Breaking Activity

Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of t...

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Published inChemical & pharmaceutical bulletin Vol. 57; no. 12; pp. 1371 - 1375
Main Authors Nakahara, Kazuhide, Takechi, Shinji, Yamaguchi, Koki, Harano, Kazunobu, Yamaguchi, Tadatoshi
Format Journal Article
LanguageEnglish
Published TOKYO The Pharmaceutical Society of Japan 01.12.2009
Pharmaceutical Soc Japan
Japan Science and Technology Agency
Subjects
Chemistry
Chemistry, Medicinal
Chemistry, Multidisciplinary
dihydropyrazine
DNA Damage - drug effects
Escherichia - drug effects
Life Sciences & Biomedicine
Models, Molecular
molecular orbital calculation
Molecular Structure
Pharmacology & Pharmacy
Physical Sciences
Pyrazines - chemistry
Pyrazines - pharmacology
Science & Technology
tetraazaindene
Tetrazolium Salts - chemistry
Tetrazolium Salts - pharmacology
thiourea
X-ray crystallography
X-ray crystallography
AGENT
BREAKAGE ACTIVITY
thiourea
molecular orbital calculation
ESCHERICHIA-COLI
dihydropyrazine
tetraazaindene
DERIVATIVES
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Summary:Dihydropyrazines (DHPs), which exhibit DNA strand-breaking activity and other biological activities associated with the generation of radical species, reacted with thiourea to give tetraazaindene (TAI) derivatives, despite thiourea is a well known radical scavenger. The structural determination of the TAIs was carried out and formation mechanism of TAI was investigated.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.57.1371