Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 17; p. 5384
• Main Authors: Sirasanagandla, Srinivasa Rao, Al-Huseini, Isehaq, Sakr, Hussein, Moqadass, Marzie, Das, Srijit, Juliana, Norsham, Abu, Izuddin Fahmy
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 24.08.2022; MDPI
• Subjects: Bisphenol A; Breastfeeding & lactation; Drinking water; Endocrine disruptors; Endocrine system; Enzymes; Epoxy resins; Exposure; Food; Health aspects; Infertility; Ingestion; Inhalation; Landfill; Lignin; Medical equipment; Molecular modelling; natural product; Natural products; Oxidative stress; Phenols; plastics; pollutant; Polycarbonates; Polyvinyl chloride; Reproductive system; Respiration; Review; Surface water; Toxicity; Toxins; treatment; Urine; South Korea; China; Malaysia; India
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27175384

Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It is widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, and topical absorption routes. The prevalence of BPA exposure has considerably increased over the past decades. Previous research studies have found a plethora of evidence of BPA’s harmful effects. Interestingly, even at a lower concentration, this industrial product was found to be harmful at cellular and tissue levels, affecting various body functions. A noble and possible treatment could be made plausible by using natural products (NPs). In this review, we highlight existing experimental evidence of NPs against BPA exposure-induced adverse effects, which involve the body’s reproductive, neurological, hepatic, renal, cardiovascular, and endocrine systems. The review also focuses on the targeted signaling pathways of NPs involved in BPA-induced toxicity. Although potential molecular mechanisms underlying BPA-induced toxicity have been investigated, there is currently no specific targeted treatment for BPA-induced toxicity. Hence, natural products could be considered for future therapeutic use against adverse and harmful effects of BPA exposure.