Label-Free Detection of Cancer Biomarkers Using an In-Line Taper Fiber-Optic Interferometer and a Fiber Bragg Grating

A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refracti...

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Bibliographic Details
Published inSensors (Basel, Switzerland) Vol. 17; no. 11; p. 2559
Main Authors Sun, Dandan, Ran, Yang, Wang, Guanjun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.11.2017
MDPI
Subjects
Biomarkers
Breast cancer
cancer biomarker
FBG
fiber taper interferometer
optical biosensor
Optical fibers
Refractivity
Sensors
optical biosensor
fiber taper interferometer
FBG
cancer biomarker
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Summary:A compact and label-free optical fiber sensor based on a taper interferometer cascaded with a fiber Bragg grating (FBG) is proposed and experimentally demonstrated for detection of a breast cancer biomarker (HER2). The tapered fiber-optic interferometer is extremely sensitive to the ambient refractive index (RI). In addition, being insensitive to the RI variation, the FBG can be applied as a temperature thermometer due to its independent response to the temperature. Surface functionalization to the sensor is carried out to achieve specific targeting of the unlabeled biomarkers. The result shows that the proposed sensor presents a low limit-of-detection (LOD) of 2 ng/mL, enabling its potentials of application in early diagnosis on the breast cancer.
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ISSN:1424-8220
1424-8220
DOI:10.3390/s17112559