Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of t...

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Bibliographic Details
Published inCancer cell Vol. 21; no. 3; pp. 309 - 322
Main Authors Hanahan, Douglas, Coussens, Lisa M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 20.03.2012
Subjects
Cell Movement
Cell Proliferation
Humans
Models, Biological
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - immunology
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - physiology
Signal Transduction
Stromal Cells - pathology
Tumor Microenvironment
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Summary:Mutationally corrupted cancer (stem) cells are the driving force of tumor development and progression. Yet, these transformed cells cannot do it alone. Assemblages of ostensibly normal tissue and bone marrow-derived (stromal) cells are recruited to constitute tumorigenic microenvironments. Most of the hallmarks of cancer are enabled and sustained to varying degrees through contributions from repertoires of stromal cell types and distinctive subcell types. Their contributory functions to hallmark capabilities are increasingly well understood, as are the reciprocal communications with neoplastic cancer cells that mediate their recruitment, activation, programming, and persistence. This enhanced understanding presents interesting new targets for anticancer therapy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2012.02.022