Gene regulation by Y-box proteins: coupling control of transcription and translation

Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have the capacity to exert positive and negative effects on both transcription and translation. In Xenopus oocytes, they help to mask maternal mRNA and couple the transcription of mRNA in the nucleus to its tran...

Full description

Saved in:
Bibliographic Details
Published inTrends in cell biology Vol. 8; no. 8; pp. 318 - 323
Main Authors Matsumoto, Ken, Wolffe, Alan P
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.1998
Subjects
Animals
Gene Expression Regulation
Humans
Nucleic Acids - metabolism
oocyte
Oocytes - metabolism
Phosphorylation
Protein Biosynthesis
RNA splicing
RNA-Binding Proteins - metabolism
RNA-Binding Proteins - physiology
RNP
splicing factor
transcription
Transcription Factors - metabolism
Transcription Factors - physiology
transcription initiation
Transcription, Genetic
translation initiation
Xenopus
Xenopus
oocyte
transcription initiation
transcription
RNP
translation initiation
RNA splicing
splicing factor
Online AccessGet full text

Cover

More Information
Summary:Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have the capacity to exert positive and negative effects on both transcription and translation. In Xenopus oocytes, they help to mask maternal mRNA and couple the transcription of mRNA in the nucleus to its translational fate in the cytoplasm. This review describes how the capacity of the Y-box proteins to destabilize both RNA and DNA duplexes, together with their distribution between nuclear and cytoplasmic compartments, might explain these multiple roles.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(98)01300-2