Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory
Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awak...
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| Published in | Science (American Association for the Advancement of Science) Vol. 363; no. 6430; pp. 975 - 978 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Association for the Advancement of Science
01.03.2019
The American Association for the Advancement of Science |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain. |
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| AbstractList | Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain. Coupled ripples in memoryShort-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little evidence linking ripple activity with awake memory retrieval in humans. Vaz et al. analyzed intracranial recordings in human subjects (see the Perspective by Gelinas). They found that ripple oscillations in the brain's medial temporal lobe were coupled with ripple oscillations in the temporal cortex. This coupling was enhanced just before successful memory retrieval. During successful retrievals with ripples, patterns of oscillations were recapitulated across multiple electrodes, consistent with the initial encoding. The observation that ripple oscillations occur before successful memory retrieval suggests that they may play a mechanistic role in the retrieval process.Science, this issue p. 975; see also p. 927Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain. Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain. Short-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little evidence linking ripple activity with awake memory retrieval in humans. Vaz et al. analyzed intracranial recordings in human subjects (see the Perspective by Gelinas). They found that ripple oscillations in the brain's medial temporal lobe were coupled with ripple oscillations in the temporal cortex. This coupling was enhanced just before successful memory retrieval. During successful retrievals with ripples, patterns of oscillations were recapitulated across multiple electrodes, consistent with the initial encoding. The observation that ripple oscillations occur before successful memory retrieval suggests that they may play a mechanistic role in the retrieval process. Science , this issue p. 975 ; see also p. 927 Intracranial EEG recordings successfully reveal the link between ripple oscillations and memory retrieval in the awake human brain. Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain. |
| Author | Vaz, Alex P. Inati, Sara K. Zaghloul, Kareem A. Brunel, Nicolas |
| AuthorAffiliation | 3 Department of Neurobiology, Duke University, Durham, NC 27710, USA 4 Office of the Clinical Director, NINDS, National Institutes of Health, Bethesda, MD 20892, USA 5 Department of Physics, Duke University, Durham, NC 27710, USA 2 Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA 1 Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892, USA |
| AuthorAffiliation_xml | – name: 1 Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, MD 20892, USA – name: 5 Department of Physics, Duke University, Durham, NC 27710, USA – name: 4 Office of the Clinical Director, NINDS, National Institutes of Health, Bethesda, MD 20892, USA – name: 2 Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA – name: 3 Department of Neurobiology, Duke University, Durham, NC 27710, USA |
| Author_xml | – sequence: 1 givenname: Alex P. surname: Vaz fullname: Vaz, Alex P. – sequence: 2 givenname: Sara K. surname: Inati fullname: Inati, Sara K. – sequence: 3 givenname: Nicolas surname: Brunel fullname: Brunel, Nicolas – sequence: 4 givenname: Kareem A. surname: Zaghloul fullname: Zaghloul, Kareem A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30819961$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/nn.3315 10.1016/j.jneumeth.2007.03.024 10.1002/hbm.23876 10.1093/brain/awn103 10.1093/cercor/bhn059 10.1016/j.neuron.2016.02.010 10.1038/nn.4119 10.1016/j.neuroimage.2010.08.002 10.1126/science.1244056 10.1523/JNEUROSCI.4156-12.2012 10.1523/JNEUROSCI.0414-13.2013 10.1016/j.neuron.2007.08.017 10.1073/pnas.1417017112 10.1002/hbm.22234 10.1136/jnnp.20.1.11 10.1016/0306-4522(89)90423-5 10.1152/jn.00077.2008 10.1038/35004588 10.1016/j.neuron.2017.06.036 10.1111/epi.13829 10.1126/science.aan6203 10.1038/nature04587 10.1038/nn.2384 10.1016/j.cub.2016.11.027 10.1038/nn.2732 10.1126/science.1217230 10.1038/nn.4543 10.1038/nn1961 10.1073/pnas.0437938100 10.1093/cercor/bhl156 10.1111/j.1528-1167.2012.03721.x 10.1016/j.neuroimage.2017.01.001 10.1016/j.psc.2005.06.002 10.1016/j.cub.2017.05.014 10.1016/j.neuron.2004.06.012 |
| ContentType | Journal Article |
| Copyright | Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works |
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| DOI | 10.1126/science.aau8956 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Author contributions: A.P.V. and K.A.Z. conceptualized the study; A.P.V. performed all data analysis, software development, and visualization; A.P.V., S.K.I., J.H.W., and K.A.Z. performed he investigation; A.P.V., J.H.W., and K.A.Z. curated the data; A.P.V. and K.A.Z. developed methodology, performed validation, and wrote the original draft; K.A.Z. acquired funding, provided resources, and performed project administration; N.B. and K.A.Z. supervised the study; A.P.V., S.K.I., N.B., and K.A.Z. reviewed and edited the final manuscript. |
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| References_xml | – ident: e_1_3_2_29_2 doi: 10.1038/nn.3315 – ident: e_1_3_2_38_2 doi: 10.1016/j.jneumeth.2007.03.024 – ident: e_1_3_2_31_2 doi: 10.1002/hbm.23876 – ident: e_1_3_2_23_2 doi: 10.1093/brain/awn103 – ident: e_1_3_2_26_2 doi: 10.1093/cercor/bhn059 – ident: e_1_3_2_21_2 doi: 10.1016/j.neuron.2016.02.010 – ident: e_1_3_2_24_2 doi: 10.1038/nn.4119 – ident: e_1_3_2_34_2 doi: 10.1016/j.neuroimage.2010.08.002 – ident: e_1_3_2_5_2 doi: 10.1126/science.1244056 – ident: e_1_3_2_9_2 doi: 10.1523/JNEUROSCI.4156-12.2012 – ident: e_1_3_2_10_2 doi: 10.1523/JNEUROSCI.0414-13.2013 – ident: e_1_3_2_4_2 doi: 10.1016/j.neuron.2007.08.017 – ident: e_1_3_2_11_2 doi: 10.1073/pnas.1417017112 – ident: e_1_3_2_30_2 doi: 10.1002/hbm.22234 – ident: e_1_3_2_2_2 doi: 10.1136/jnnp.20.1.11 – ident: e_1_3_2_7_2 doi: 10.1016/0306-4522(89)90423-5 – ident: e_1_3_2_25_2 doi: 10.1152/jn.00077.2008 – ident: e_1_3_2_27_2 doi: 10.1038/35004588 – ident: e_1_3_2_6_2 doi: 10.1016/j.neuron.2017.06.036 – ident: e_1_3_2_36_2 doi: 10.1111/epi.13829 – ident: e_1_3_2_22_2 doi: 10.1126/science.aan6203 – ident: e_1_3_2_18_2 doi: 10.1038/nature04587 – ident: e_1_3_2_17_2 doi: 10.1038/nn.2384 – ident: e_1_3_2_13_2 doi: 10.1016/j.cub.2016.11.027 – ident: e_1_3_2_20_2 doi: 10.1038/nn.2732 – ident: e_1_3_2_14_2 doi: 10.1126/science.1217230 – ident: e_1_3_2_15_2 doi: 10.1038/nn.4543 – ident: e_1_3_2_19_2 doi: 10.1038/nn1961 – ident: e_1_3_2_16_2 doi: 10.1073/pnas.0437938100 – ident: e_1_3_2_8_2 doi: 10.1093/cercor/bhl156 – ident: e_1_3_2_37_2 doi: 10.1111/j.1528-1167.2012.03721.x – ident: e_1_3_2_33_2 doi: 10.1016/j.neuroimage.2017.01.001 – ident: e_1_3_2_3_2 doi: 10.1016/j.psc.2005.06.002 – ident: e_1_3_2_12_2 doi: 10.1016/j.cub.2017.05.014 – ident: e_1_3_2_28_2 doi: 10.1016/j.neuron.2004.06.012 – ident: e_1_3_2_35_2 – ident: e_1_3_2_32_2 – reference: 30819949 - Science. 2019 Mar 1;363(6430):927-928 |
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| Snippet | Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic... Short-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There is, however, little... Coupled ripples in memoryShort-lived, high-frequency oscillations in the brain called ripples have been implicated as substrates for memory formation. There... |
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| SubjectTerms | Adult Brain Brain Mapping Communications systems Drug Resistant Epilepsy EEG Electrocorticography Electrodes Female Human-computer interaction Humans Listening comprehension Male Memory Memory and Learning Tests Memory, Episodic Mental Recall Neocortex - physiology Oscillations Recall (Psychology) Representations Retrieval Ripples Substrates Temporal lobe Temporal Lobe - physiology |
| Title | Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory |
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