Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory

Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awak...

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Published inScience (American Association for the Advancement of Science) Vol. 363; no. 6430; pp. 975 - 978
Main Authors Vaz, Alex P., Inati, Sara K., Brunel, Nicolas, Zaghloul, Kareem A.
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 01.03.2019
The American Association for the Advancement of Science
Subjects
Adult
Brain
Brain Mapping
Communications systems
Drug Resistant Epilepsy
EEG
Electrocorticography
Electrodes
Female
Human-computer interaction
Humans
Listening comprehension
Male
Memory
Memory and Learning Tests
Memory, Episodic
Mental Recall
Neocortex - physiology
Oscillations
Recall (Psychology)
Representations
Retrieval
Ripples
Substrates
Temporal lobe
Temporal Lobe - physiology
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Summary:Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.
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Author contributions: A.P.V. and K.A.Z. conceptualized the study; A.P.V. performed all data analysis, software development, and visualization; A.P.V., S.K.I., J.H.W., and K.A.Z. performed he investigation; A.P.V., J.H.W., and K.A.Z. curated the data; A.P.V. and K.A.Z. developed methodology, performed validation, and wrote the original draft; K.A.Z. acquired funding, provided resources, and performed project administration; N.B. and K.A.Z. supervised the study; A.P.V., S.K.I., N.B., and K.A.Z. reviewed and edited the final manuscript.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.aau8956