Surgical Treatment Outcomes of Patients with Non-Small Cell Lung Cancer and Lymph Node Metastases

• Published in: Cancers Vol. 15; no. 12; p. 3098
• Main Authors: Shimizu, Yuki, Koike, Terumoto, Hasebe, Toshiki, Nakamura, Masaya, Goto, Tatsuya, Toyabe, Shin-Ichi, Tsuchida, Masanori
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2023; MDPI
• Subjects: adjuvant chemotherapy; Adjuvant treatment; Cancer; Cancer therapies; Care and treatment; Chemotherapy; Comorbidity; Histology; Lung cancer; Lung cancer, Non-small cell; Lung cancer, Small cell; lymph node metastases; Lymph nodes; Lymphatic system; Magnetic resonance imaging; Metastases; Metastasis; Multivariate analysis; Non-small cell lung carcinoma; non-small-cell lung cancer; Oncology, Experimental; overall survival; Patient outcomes; Patients; Platinum; Pneumonectomy; Pneumonia; Radiation therapy; recurrence-free probability; Risk factors; Small cell lung carcinoma; Squamous cell carcinoma; Surgeons; Surgery; surgical treatment; Thoracic surgery; Tomography; Tumors; overall survival; adjuvant chemotherapy; surgical treatment; recurrence-free probability; lymph node metastases; non-small-cell lung cancer
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15123098

This study aimed to investigate the appropriate subgroups for surgery and adjuvant chemotherapy in patients with non-small-cell lung cancer (NSCLC) and nodal metastases. We retrospectively reviewed 210 patients with NSCLC and nodal metastases who underwent surgery and examined the risk factors for poor overall survival (OS) and recurrence-free probability (RFP) using multivariate Cox proportional hazards analysis. Pathological N1 and N2 were observed in 114 (52.4%) and 96 (47.6%) patients, respectively. A single positive node was identified in 102 patients (48.6%), and multiple nodes were identified in 108 (51.4%). Multivariate analysis revealed that vital capacity < 80% (hazard ratio [HR]: 2.678, 95% confidence interval [CI]: 1.483-4.837), radiological usual interstitial pneumonia pattern (HR: 2.321, 95% CI: 1.506-3.576), tumor size > 4.0 cm (HR: 1.534, 95% CI: 1.035-2.133), and multiple-node metastases (HR: 2.283, 95% CI: 1.517-3.955) were significant independent risk factors for poor OS. Tumor size > 4.0 cm (HR: 1.780, 95% CI: 1.237-2.562), lymphatic permeation (HR: 1.525, 95% CI: 1.053-2.207), and multiple lymph node metastases (HR: 2.858, 95% CI: 1.933-4.226) were significant independent risk factors for recurrence. In patients with squamous cell carcinoma ( = 93), there were no significant differences in OS or RFP between those who received platinum-based adjuvant chemotherapy ( = 25) and those who did not ( = 68), at = 0.690 and = 0.292, respectively. Multiple-node metastases were independent predictors of poor OS and recurrence. Patients with NSCLC and single-node metastases should be considered for surgery despite N2 disease. Additional treatment with platinum-based adjuvant chemotherapy may be expected, especially in patients with squamous cell carcinoma.