Photocontrollable mononegaviruses

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 24; pp. 11587 - 11589
• Main Authors: Tahara, Maino, Takishima, Yuto, Miyamoto, Shohei, Nakatsu, Yuichiro, Someya, Kenji, Sato, Moritoshi, Tani, Kenzaburo, Takeda, Makoto
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.06.2019
• Series: Brief Report
• Subjects: Animals; Biological Sciences; BRIEF REPORT; Cell Line, Tumor; DNA-Directed RNA Polymerases - genetics; Expression vectors; Gene therapy; Genetic Therapy - methods; Genetic Vectors - genetics; Humans; Illumination; Light; Measles; Measles virus - genetics; Mice, Inbred BALB C; Mice, Nude; Oncolysis; Oncolytic Virotherapy - methods; Oncolytic Viruses - genetics; Proteins; Rabies; Rabies virus - genetics; Regenerative medicine; Transgenes - genetics; Virus Replication - genetics; Viruses; rabies virus; mononegavirus; vector; oncolytic; measles virus

Mononegaviruses are promising tools as oncolytic vectors and transgene delivery vectors for gene therapy and regenerative medicine. By using the Magnet proteins, which reversibly heterodimerize upon blue light illumination, photocontrollable mononegaviruses (measles and rabies viruses) were generate...