High sensitivity and interindividual variability in the response of the human circadian system to evening light

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 24; pp. 12019 - 12024
• Main Authors: Phillips, Andrew J. K., Vidafar, Parisa, Burns, Angus C., McGlashan, Elise M., Anderson, Clare, Rajaratnam, Shantha M. W., Lockley, Steven W., Cain, Sean W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.06.2019
• Subjects: Adult; Biological Sciences; Circadian Clocks - physiology; Circadian rhythm; Circadian Rhythm - physiology; Circadian rhythms; Coefficient of variation; Disruption; Dosage; Environmental effects; Evening; Exposure; Female; Human behavior; Humans; Individuality; Light; Light levels; Lighting; Lighting - methods; Luminous intensity; Male; Melatonin; Melatonin - metabolism; Sensitivity; Young Adult; melatonin suppression; evening light; light sensitivity; circadian rhythms; circadian disruption
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.1901824116

Before the invention of electric lighting, humans were primarily exposed to intense (>300 lux) or dim (<30 lux) environmental light—stimuli at extreme ends of the circadian system’s dose–response curve to light. Today, humans spend hours per day exposed to intermediate light intensities (30–300 lux), particularly in the evening. Interindividual differences in sensitivity to evening light in this intensity range could therefore represent a source of vulnerability to circadian disruption by modern lighting. We characterized individual-level dose–response curves to light-induced melatonin suppression using a within-subjects protocol. Fifty-five participants (aged 18–30) were exposed to a dim control (<1 lux) and a range of experimental light levels (10–2,000 lux for 5 h) in the evening. Melatonin suppression was determined for each light level, and the effective dose for 50% suppression (ED50) was computed at individual and group levels. The group-level fitted ED50 was 24.60 lux, indicating that the circadian system is highly sensitive to evening light at typical indoor levels. Light intensities of 10, 30, and 50 lux resulted in later apparent melatonin onsets by 22, 77, and 109 min, respectively. Individual-level ED50 values ranged by over an order of magnitude (6 lux in the most sensitive individual, 350 lux in the least sensitive individual), with a 26% coefficient of variation. These findings demonstrate that the same evening-light environment is registered by the circadian system very differently between individuals. This interindividual variability may be an important factor for determining the circadian clock’s role in human health and disease.