Relationship between sagittal balance and adjacent segment disease in surgical treatment of degenerative lumbar spine disease: meta-analysis and implications for choice of fusion technique

• Published in: European spine journal Vol. 27; no. 8; pp. 1981 - 1991
• Main Authors: Phan, Kevin, Nazareth, Alexander, Hussain, Awais K., Dmytriw, Adam A., Nambiar, Mithun, Nguyen, Damian, Kerferd, Jack, Phan, Steven, Sutterlin, Chet, Cho, Samuel K., Mobbs, Ralph J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer Nature B.V
• Subjects: Aged; Back surgery; Decision making; Degenerative disc disease; Disease; Female; Humans; Intervertebral Disc Degeneration - etiology; Intervertebral Disc Degeneration - pathology; Intervertebral Disc Degeneration - surgery; Lumbar Vertebrae - surgery; Male; Medicine; Medicine & Public Health; Meta-analysis; Middle Aged; Neurosurgery; Patients; Pelvic Bones - pathology; Postoperative Complications; Reoperation; Retrospective Studies; Review; Risk Factors; Spinal Fusion - adverse effects; Spinal Fusion - methods; Spine (lumbar); Surgery; Surgical Orthopedics; Systematic review; Lumbar degeneration; Sagittal alignment; Lumbar lordosis; Spinopelvic parameters; Adjacent segment disease; Deformity; Pelvic incidence; Sagittal compensate
• ISSN: 0940-6719; 1432-0932
• DOI: 10.1007/s00586-018-5629-6

Study design Meta-analysis. Objective To conduct a meta-analysis investigating the relationship between spinopelvic alignment parameters and development of adjacent level disease (ALD) following lumbar fusion for degenerative disease. Summary of background data ALD is a degenerative pathology that develops at mobile segments above or below fused spinal segments. Patient outcomes are worse, and the likelihood of requiring revision surgery is higher in ALD compared to patients without ALD. Spinopelvic sagittal alignment has been found to have a significant effect on outcomes post-fusion; however, studies investigating the relationship between spinopelvic sagittal alignment parameters and ALD in degenerative lumbar disease are limited. Methods Six e-databases were searched. Predefined endpoints were extracted and meta-analyzed from the identified studies. Results There was a significantly larger pre-operative PT in the ALD cohort versus control (WMD 3.99, CI 1.97–6.00, p  = 0.0001), a smaller pre-operative SS (WMD − 2.74; CI − 5.14 to 0.34, p  = 0.03), and a smaller pre-operative LL (WMD − 4.76; CI − 7.66 to 1.86, p  = 0.001). There was a significantly larger pre-operative PI-LL in the ALD cohort (WMD 8.74; CI 3.12–14.37, p  = 0.002). There was a significantly larger postoperative PI in the ALD cohort (WMD 2.08; CI 0.26–3.90, p  = 0.03) and a larger postoperative PT (WMD 5.23; CI 3.18–7.27, p  < 0.00001). Conclusion The sagittal parameters: PT, SS, PI-LL, and LL may predict development of ALD in patients’ post-lumbar fusion for degenerative disease. Decision-making aimed at correcting these parameters may decrease risk of developing ALD in this cohort. Graphical abstract These slides can be retrieved under Electronic Supplementary Material.