Changes of shear-wave velocity by interferon-based therapy in chronic hepatitis C

AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured w...

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Published inWorld journal of gastroenterology : WJG Vol. 21; no. 35; pp. 10215 - 10223
Main Authors Osakabe, Keisuke, Ichino, Naohiro, Nishikawa, Toru, Sugiyama, Hiroko, Kato, Miho, Shibata, Ai, Asada, Wakana, Kawabe, Naoto, Hashimoto, Senju, Murao, Michihito, Nakano, Takuji, Shimazaki, Hiroaki, Kan, Toshiki, Nakaoka, Kazunori, Takagawa, Yuka, Ohki, Masashi, Kurashita, Takamitsu, Takamura, Tomoki, Yoshioka, Kentaro
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Inc 21.09.2015
Subjects
Adult
Aged
and
Antiviral Agents - therapeutic use
Drug Therapy, Combination
Elasticity Imaging Techniques
Female
Hepatitis
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - virology
Humans
Interferon alpha-2
Interferon-alpha - therapeutic use
Liver - drug effects
Liver - pathology
Liver - virology
Liver Cirrhosis - diagnosis
Liver Cirrhosis - drug therapy
Liver Cirrhosis - virology
Male
Middle Aged
Observational Study
Polyethylene Glycols - therapeutic use
Predictive Value of Tests
Recombinant Proteins - therapeutic use
ribaviri
Ribavirin - therapeutic use
Time Factors
Treatment Outcome
virus;Fibrosis;Interferon
Liver stiffness
Shear-wave velocity
Hepatitis C virus
Interferon and ribavirin
Fibrosis
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Summary:AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after EOT.RESULTS: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.
Bibliography:Hepatitis C virus;Fibrosis;Interferon and ribaviri
AIM: To evaluate the changes of shear-wave velocity(Vs) by acoustic radiation force impulse after treatment in chronic hepatitis C.METHODS: Eighty-seven patients with chronic hepatitis C were consecutively treated with combinations of interferon(IFN) plus ribavirin(RBV). Vs value(m/s) was measured with acoustic radiation force impulse before treatment, at end of treatment(EOT), 1 year after EOT, and 2 years after EOT.RESULTS: In patients with a sustained virological response(SVR)(n = 41), Vs significantly decreased at EOT [1.19(1.07-1.37), P = 0.0004], 1 year after EOT [1.10(1.00-1.22), P = 0.0001], and 2 years after EOT [1.05(0.95-1.16), P < 0.0001] compared with baseline [1.27(1.11-1.49)]. In patients with a relapse(n = 26), Vs did not significantly decrease at EOT [1.23(1.12-1.55)], 1 year after EOT [1.20(1.12-1.80)], and 2 years after EOT [1.41(1.08-2.01)] compared with baseline [1.39(1.15-1.57)]. In patients with a nonvirological response(n = 20), Vs did not significantly decrease at EOT [1.64(1.43-2.06)], 1 year after EOT [1.66(1.30-1.95)], and 2 years after EOT [1.61(1.36-2.37)] compared with baseline [1.80(1.54-2.01)]. Among genotype 1 patients, baseline Vs was significantly lower in SVR patients [1.28(1.04-1.40)] than in non-SVR patients [1.56(1.20-1.83)](P = 0.0142).CONCLUSION: Reduction of Vs values was shown in SVR patients after IFN-plus-RBV therapy by acoustic radiation force impulse.
Keisuke Osakabe;Naohiro Ichino;Toru Nishikawa;Hiroko Sugiyama;Miho Kato;Ai Shibata;Wakana Asada;Naoto Kawabe;Senju Hashimoto;Michihito Murao;Takuji Nakano;Hiroaki Shimazaki;Toshiki Kan;Kazunori Nakaoka;Yuka Takagawa;Masashi Ohki;Takamitsu Kurashita;Tomoki Takamura;Kentaro Yoshioka;Faculty of Medical Technology,School of Health Sciences,Fujita Health University;Center of Ultrasound Diagnosis,Fujita Health University Hospital;Department of Liver,Biliary Tract and Pancreas Diseases,Fujita Health University
Telephone: +81-562-932324 Fax: +81-562-938601
Author contributions: Osakabe K, Kawabe N and Yoshioka K contributed to this work; Osakabe K, Kawabe N and Yoshioka K designed the research; Osakabe K, Kawabe N, Hashimoto S, Murao M, Nakano T, Sugiyama H, Shimazaki H, Kan T, Nakaoka K, Ohki M, Takagawa Y, Kurashita T and Takamura T performed the research; Osakabe K, Ichino N, Nishikawa T, Sugiyama H, Kato M, Shibata A and Asada W collected and analyzed the data; Osakabe K wrote the paper; and Yoshioka K contributed to discussion.
Correspondence to: Kentaro Yoshioka, MD, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470-1192, Japan. kyoshiok@fujita-hu.ac.jp
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v21.i35.10215