HoxB13 mediates AR-V7 activity in prostate cancer

Prostate cancer remains a leading cause of cancer death in the US. In 2017, it was estimated that over 160,000 prostate cancer cases were diagnosed in the United States, and ~26,000 men died of prostate cancer. Because tumor growth in prostate cancer is predominantly dependent on the androgen recept...

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Published inProceedings of the National Academy of Sciences - PNAS Vol. 115; no. 26; pp. 6528 - 6529
Main Authors Navarro, Héctor I., Goldstein, Andrew S.
Format Journal Article
LanguageEnglish
Published United States National Academy of Sciences 26.06.2018
Subjects
Androgen receptors
Androgens
Antigens
Biological Sciences
Cancer
Cancer therapies
Castration
Cell Line, Tumor
Commentaries
COMMENTARY
Homeodomain Proteins
Humans
Male
Patients
Prostate cancer
Prostate-specific antigen
Prostatic Neoplasms
Prostatic Neoplasms, Castration-Resistant
Receptors, Androgen
Tumors
United States > US
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Summary:Prostate cancer remains a leading cause of cancer death in the US. In 2017, it was estimated that over 160,000 prostate cancer cases were diagnosed in the United States, and ~26,000 men died of prostate cancer. Because tumor growth in prostate cancer is predominantly dependent on the androgen receptor (AR), a homodimer-forming transcription factor, the disease is commonly treated via therapies targeting the AR-axis. While this approach has proven to be initially effective, a majority of prostate cancer patients eventually develop resistance to AR-targeting therapies, leading to castration-resistant prostate cancer, the lethal stage of prostate cancer. Measuring prostate-specific antigen levels in patient serum is regularly used for evaluating the efficacy of prostate cancer treatment. Here, Navarro and Goldstein discuss how HoxB13 mediates AR-V7 activity in prostate cancer.
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Author contributions: H.I.N. and A.S.G. wrote the paper.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1808196115