Paper-filtered coffee increases cholesterol and inflammation biomarkers independent of roasting degree: A clinical trial

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 29; no. 7; pp. 977 - 981
• Main Authors: Corrêa, Telma A.F., Ph.D, Rogero, Marcelo M., Ph.D, Mioto, Bruno M., B.D, Tarasoutchi, Daniela, B.S, Tuda, Vera L., B.S, César, Luiz A.M., Ph.D, Torres, Elizabeth A.F.S., Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2013; Elsevier; Elsevier Limited
• Subjects: Adult; Antioxidants; Biological and medical sciences; Biomarkers - blood; Blood Glucose - analysis; Blood Pressure; Body mass index; Cardiovascular disease; Cardiovascular Diseases - physiopathology; Cholesterol; Cholesterol - blood; Coffee; Coffee - adverse effects; Coffee - chemistry; Cross-Over Studies; Diet; E-Selectin - blood; Endothelial dysfunction; Feeding. Feeding behavior; Female; Fibrinogen - metabolism; Filtration; Food Handling; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Healthy Volunteers; Homocysteine - blood; Humans; Inflammation; Inflammation - metabolism; Inflammation - physiopathology; Insulin resistance; Lipoprotein(a) - blood; Male; Middle Aged; Proteins; Risk Factors; Vascular Cell Adhesion Molecule-1 - blood; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Antioxidants; Endothelial dysfunction; Cardiovascular disease; Inflammation; Coffee; Cholesterol; Risk factors; Nutrition; Biological marker; Lipids; Antioxidant; Risk factor; Clinical trial
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2013.01.003

Abstract Objective The aim of this study was to compare the effects of medium light roast (MLR) and medium roast (MR) paper-filtered coffee on cardiovascular risk factors in healthy volunteers. Methods This randomized crossover trial compared the effects of consuming three or four cups (150 mL) of MLR or MR coffee per day for 4 wk in 20 healthy volunteers. Plasma lipids, lipoprotein(a) (Lp[a]), total homocysteine, and endothelial dysfunction–related inflammation biomarkers, serum glycemic biomarkers, and blood pressure were measured at baseline and after each intervention. Results Both roasts increased plasma total cholesterol, low-density lipoprotein-cholesterol, and soluble vascular cell adhesion molecule-1 (sVCAM-1) concentrations (10%, 12%, and 18% for MLR; 12%, 14%, and 14% for MR, respectively) ( P < 0.05). MR also increased high-density lipoportein-cholesterol concentration by 7% ( P = 0.003). Plasma fibrinogen concentration increased 8% after MR intake ( P = 0.01), and soluble E-selectin increased 12% after MLR intake ( P = 0.02). No changes were observed for Lp(a), total homocysteine, glycemic biomarkers, and blood pressure. Conclusion Moderate paper-filtered coffee consumption may have an undesirable effect on plasma cholesterol and inflammation biomarkers in healthy individuals regardless of its antioxidant content.