A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intensely pruritic subacute and chronic eczematous plaques, the pathogenesis of which appears to involve a complex interplay of genetic, pharmacological, environmental and psychological factors. Here, Markus Grewe and col...

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Published inImmunology today (Amsterdam. Regular ed.) Vol. 19; no. 8; pp. 359 - 361
Main Authors Grewe, Markus, Bruijnzeel-Koomen, Carla A.F.M, Schöpf, Erwin, Thepen, Theo, Langeveld-Wildschut, Alice G, Ruzicka, Thomas, Krutmann, Jean
Format Journal Article
LanguageEnglish
Published England Elsevier B.V 01.08.1998
Subjects
AIDS/HIV
Animals
atopic dermatitis
atopy
Dermatitis, Atopic - immunology
eosinophils
Humans
interferon γ
interleukin 4
Interleukin-10 - biosynthesis
Interleukin-2 - biosynthesis
patch-test
Th1
Th1 Cells - immunology
Th2
Th2 Cells - immunology
interleukin 4
interferon γ
atopy
atopic dermatitis
eosinophils
Th1
patch-test
Th2
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Summary:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intensely pruritic subacute and chronic eczematous plaques, the pathogenesis of which appears to involve a complex interplay of genetic, pharmacological, environmental and psychological factors. Here, Markus Grewe and colleagues propose that the development of skin lesions in AD patients results from sequential activation of T helper 2 (Th2)- and Th1-type cells.
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ISSN:0167-5699
DOI:10.1016/S0167-5699(98)01285-7