Aromatase inhibitors prevent spontaneous granular cell tumors in the distal female reproductive tract of Sprague-Dawley rats

• Published in: Toxicologic pathology Vol. 28; no. 6; p. 799
• Main Authors: Markovits, J E, Sahota, P S
• Format: Journal Article
• Language: English
• Published: United States 01.11.2000
• Subjects: Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors - pharmacology; Fadrozole - pharmacology; Female; Granular Cell Tumor - enzymology; Granular Cell Tumor - pathology; Granular Cell Tumor - prevention & control; Nitriles - pharmacology; Rats; Rats, Sprague-Dawley; Triazoles - pharmacology; Uterine Cervical Neoplasms - enzymology; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - prevention & control; Vaginal Neoplasms - enzymology; Vaginal Neoplasms - pathology; Vaginal Neoplasms - prevention & control
• ISSN: 0192-6233
• DOI: 10.1177/019262330002800605

We recently established diagnostic criteria for granular cell changes in the distal female reproductive tract of rats. In a review of control animals from 9 carcinogenicity studies, we found that approximately 23% of animals had granular cell alterations. Because estrogen may play a role in the pathogenesis of granular cell alterations, we reviewed tissue sections from carcinogenicity studies with 2 aromatase inhibitors and found compound-related decreases in the incidence of granular cell changes. Since these aromatase inhibitors selectively prevent the conversion of androgenic steroids to the corresponding estrogens, these data further suggest that estrogen may play a role in the pathogenesis of granular cell tumors of the reproductive tract of rats.