Motor Cortical Plasticity Induced by Volitional Muscle Activity-Triggered Transcranial Magnetic Stimulation and Median Nerve Stimulation

• Published in: Brain sciences Vol. 12; no. 1; p. 61
• Main Authors: Kariyawasam, Pramudika Nirmani, Suzuki, Shinya, Yoshida, Susumu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.12.2021; MDPI
• Subjects: Activities of daily living; bilateral training; Cortex (motor); Electrodes; Electromyography; Excitability; functional electrical stimulation; Hypotheses; Intervention; Magnetic fields; Median nerve; Methods; Motor evoked potentials; Muscle contraction; Muscle function; Neural plasticity; neuroplasticity; Paresis; Peripheral nerves; Pyramidal tracts; Transcranial magnetic stimulation; United Kingdom > UK; Japan; functional electrical stimulation; transcranial magnetic stimulation; bilateral training; neuroplasticity
• ISSN: 2076-3425; 2076-3425
• DOI: 10.3390/brainsci12010061

Bilateral motor training is a useful method for modifying corticospinal excitability. The effects of bilateral movement that are caused by artificial stimulation on corticospinal excitability have not been reported. We compared motor-evoked potentials (MEPs) of the primary motor cortex (M1) after conventional bilateral motor training and artificial bilateral movements generated by electromyogram activity of abductor pollicis brevis (APB) muscle-triggered peripheral nerve stimulation (c-MNS) and transcranial magnetic stimulation of the ipsilateral M1 (i-TMS). A total of three protocols with different interventions-bilateral finger training, APB-triggered c-MNS, and APB-triggered i-TMS-were administered to 12 healthy participants. Each protocol consisted of 360 trials of 30 min for each trial. MEPs that were induced by single-pulse TMS, short-interval intracortical inhibition (SICI), and intracortical facilitation (ICF) that were induced by paired-pulse TMS were assessed as outcome measures at baseline and at 0, 20, 40, and 60 min after intervention. MEP amplitude significantly increased up to 40 min post-intervention in all protocols compared to that at the baseline, although there were some differences in the changing pattern of ICF and SICI in each protocol. These findings suggest that artificial bilateral movement has the potential to increase the ipsilateral cortical excitability of the moving finger.