Recognizing death: the phagocytosis of apoptotic cells

Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself, but an increasing number of recent studies are highlighting...

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Bibliographic Details
Published inTrends in cell biology Vol. 8; no. 9; pp. 365 - 372
Main Authors Platt, Nick, da Silva, Rosangela P, Gordon, Siamon
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.1998
Subjects
Animals
apolipoprotein B
Apoptosis
CD36 Antigens - physiology
macrophage
Membrane Proteins
phagocyte
Phagocytosis
Receptors, Immunologic - physiology
Receptors, Lipoprotein
Receptors, Scavenger
scavenger receptor
Scavenger Receptors, Class B
phagocytosis
macrophage
scavenger receptor
apolipoprotein B
phagocyte
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Summary:Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself, but an increasing number of recent studies are highlighting its importance. This review discusses the nature of the receptors that have been implicated in apoptotic cell phagocytosis, the mechanisms of uptake and the immunological consequences of apoptotic cell ingestion.
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ISSN:0962-8924
1879-3088
DOI:10.1016/S0962-8924(98)01329-4