Tumor vessel normalization and immunotherapy in gastric cancer

Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization...

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Published inTherapeutic Advances in Medical Oncology Vol. 14; pp. 175883592211101 - 17588359221110176
Main Authors Yu, Xianzhe, He, Shan, Shen, Jian, Huang, Qiushi, Yang, Peng, Huang, Lin, Pu, Dan, Wang, Li, Li, Lu, Liu, Jinghua, Liu, Zelong, Zhu, Lingling
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 2022
Sage Publications Ltd
SAGE Publishing
Subjects
Angiogenesis
Cancer immunotherapy
Gastric cancer
Immune response
Immunomodulation
Review
Survival
Tumor microenvironment
Tumors
Vascular endothelial growth factor
immune microenvironment
immune checkpoint inhibitors
gastric cancer
vessel normalization
immunotherapy
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Summary:Gastric cancer (GC) is a common malignant tumor, and patients with GC have a low survival rate due to limited effective treatment methods. Angiogenesis and immune evasion are two key processes in GC progression, and they act synergistically to promote tumor progression. Tumor vascular normalization has been shown to improve the efficacy of cancer immunotherapy, which in turn may be improved through enhanced immune stimulation. Therefore, it may be interesting to identify synergies between immunomodulatory agents and anti-angiogenic therapies in GC. This strategy aims to normalize the tumor microenvironment through the action of the anti-vascular endothelial growth factor while stimulating the immune response through immunotherapy and prolonging the survival of GC patients.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
First author
ISSN:1758-8359
1758-8340
1758-8359
DOI:10.1177/17588359221110176