Long-term in vitro degradation behavior and biocompatibility of polycaprolactone/cobalt-substituted hydroxyapatite composite for bone tissue engineering

• Published in: Dental materials Vol. 35; no. 5; pp. 751 - 762
• Main Authors: Lin, Wei-Chun, Yao, Chenmin, Huang, Ting-Yun, Cheng, Shih-Jung, Tang, Cheng-Ming
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.05.2019; Elsevier BV
• Subjects: Anti-inflammatory; Antibacterial; Biocompatibility; Biocompatible Materials; Biodegradability; Biodegradation; Biomedical materials; Bone growth; Bone induction; Bone Regeneration; Bones; Buffer solutions; Calcium; Cell culture; Cell Proliferation; Chemical composition; Cobalt; Cobalt-substituted hydroxyapatite; Crystal structure; Differentiation (biology); Durapatite; E coli; Escherichia coli; Free radicals; Hydroxyapatite; Infections; Inflammation; Inflammatory response; Membranes; Morphology; Organic chemistry; Osteogenesis; Polycaprolactone; Polyesters; Powder; Regeneration; Regeneration (physiology); Substitutes; Surgical implants; Therapeutic applications; Thermal properties; Thermodynamic properties; Tissue Engineering; Tissue Scaffolds; Biodegradation; Bone induction; Antibacterial; Cobalt-substituted hydroxyapatite; Polycaprolactone; Anti-inflammatory

[Display omitted] •The degradation behavior of PCL and PCL–CoHA membranes was analyzed by long-term immersion (6 months).•Accelerate the degradation of PCL membrane by added CoHA.•PCL–CoHA membrane favors MG63 cell attachment, proliferation and differentiation.•PCL–CoHA membrane significantly inhibi...