CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

Currently, a new gene editing tool-the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system-is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, ha...

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Bibliographic Details
Published inViruses Vol. 10; no. 1; p. 40
Main Authors Chen, Shuliang, Yu, Xiao, Guo, Deyin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 16.01.2018
MDPI
Subjects
Animals
antiviral strategy
CRISPR
CRISPR-Cas
CRISPR-Cas Systems
Gene Editing
Gene Targeting
Genes
Genome editing
Genome, Viral
Genomes
host genes
Host-Pathogen Interactions - genetics
Humans
Immune system
Mice
Nucleic acids
Prokaryotes
Review
virus
Virus Diseases - genetics
CRISPR-Cas
gene targeting
antiviral strategy
host genes
virus
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Summary:Currently, a new gene editing tool-the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system-is becoming a promising approach for genetic manipulation at the genomic level. This simple method, originating from the adaptive immune defense system in prokaryotes, has been developed and applied to antiviral research in humans. Based on the characteristics of virus-host interactions and the basic rules of nucleic acid cleavage or gene activation of the CRISPR-Cas system, it can be used to target both the virus genome and host factors to clear viral reservoirs and prohibit virus infection or replication. Here, we summarize recent progress of the CRISPR-Cas technology in editing host genes as an antiviral strategy.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1999-4915
1999-4915
DOI:10.3390/v10010040