Transcranial DC stimulation (tDCS): A tool for double-blind sham-controlled clinical studies in brain stimulation

• Published in: Clinical neurophysiology Vol. 117; no. 4; pp. 845 - 850
• Main Authors: Gandiga, Prateek C., Hummel, Friedhelm C., Cohen, Leonardo G.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.04.2006; Elsevier Science
• Subjects: Aged; Attention - physiology; Biological and medical sciences; Clinical Trials as Topic - methods; Clinical Trials as Topic - standards; Cues; DC stimulation; Double-Blind Method; Double-blinding; Electric Stimulation Therapy - adverse effects; Electric Stimulation Therapy - methods; Electric Stimulation Therapy - trends; Electrodiagnosis. Electric activity recording; Fatigue - etiology; Fatigue - physiopathology; Feasibility Studies; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Motor Cortex - physiology; Nervous system; Neurology; Neurorehabilitation; Paresthesia - etiology; Paresthesia - physiopathology; Sensation Disorders - etiology; Sensation Disorders - physiopathology; Sham stimulation; Stroke; Stroke Rehabilitation; Treatment Outcome; Vascular diseases and vascular malformations of the nervous system; CSP; Stroke; tDCS; Sham stimulation; MMSE; DC stimulation; Double-blinding; VAS; Neurorehabilitation; rTMS; HV; Motor pathway; Central nervous system; Cardiovascular disease; Motor learning; Vascular disease; Electrodiagnosis; Acquisition process; Direct current; Motor cortex; Clinical trial; Motricity; Cerebrovascular disease; Ability; Human; Sensation; Nervous system diseases; Attention; Fatigue; Cerebral disorder; Central nervous system disease; Strategy; Feasibility
• ISSN: 1388-2457; 1872-8952
• DOI: 10.1016/j.clinph.2005.12.003

Brain polarization in the form of transcranial direct current stimulation (tDCS), which influences motor function and learning processes, has been proposed as an adjuvant strategy to enhance training effects in Neurorehabilitation. Proper testing in Neurorehabilitation requires double-blind sham-controlled study designs. Here, we evaluated the effects of tDCS and sham stimulation (SHAM) on healthy subjects and stroke patients' self-report measures of attention, fatigue, duration of elicited sensations and discomfort. tDCS or SHAM was in all cases applied over the motor cortex. Attention, fatigue, and discomfort were self rated by study participants using visual analog scales. Duration of perceived sensations and the ability to distinguish tDCS from Sham sessions were determined. Investigators questioning the patients were blind to the intervention type. tDCS and SHAM elicited comparably minimal discomfort and duration of sensations in the absence of differences in attention or fatigue, and could not be distinguished from SHAM by study participants nor investigators. Successful blinding of subjects and investigators and ease of application simultaneously with training protocols supports the feasibility of using tDCS in double-blind, sham-controlled randomized trials in clinical Neurorehabilitation. tDCS could evolve into a useful tool, in addition to TMS, to modulate cortical activity in Neurorehabilitation.