Progesterone-Related Immune Modulation of Pregnancy and Labor

Pregnancy involves a complex interplay between maternal neuroendocrine and immunological systems in order to establish and sustain a growing fetus. It is thought that the uterus at pregnancy transitions from quiescent to laboring state in response to interactions between maternal and fetal systems a...

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Published inFrontiers in endocrinology (Lausanne) Vol. 10; p. 198
Main Authors Shah, Nishel M, Lai, Pei F, Imami, Nesrina, Johnson, Mark R
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 29.03.2019
Subjects
Endocrinology
immune modulation
immune response
PIBF
pregnancy
progesterone
PIBF
immune modulation
immune response
pregnancy
progesterone
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Summary:Pregnancy involves a complex interplay between maternal neuroendocrine and immunological systems in order to establish and sustain a growing fetus. It is thought that the uterus at pregnancy transitions from quiescent to laboring state in response to interactions between maternal and fetal systems at least partly altered neuroendocrine signaling. Progesterone (P4) is a vital hormone in maternal reproductive tissues and immune cells during pregnancy. As such, P4 is widely used in clinical interventions to improve the chance of embryo implantation, as well as reduce the risk of miscarriage and premature labor. Here we review research to date that focus on the pathways through which P4 mediates its actions on both the maternal reproductive and immune system. We will dissect the role of P4 as a modulator of inflammation, both systemic and intrinsic to the uterus, during human pregnancy and labor.
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Edited by: Elke Winterhager, University of Duisburg-Essen, Germany
This article was submitted to Reproduction, a section of the journal Frontiers in Endocrinology
Reviewed by: Ana Claudia Zenclussen, Universitätsklinikum Magdeburg, Germany; Maria Emilia Solano, University Medical Center Hamburg-Eppendorf, Germany
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2019.00198