Tone-Dependent Waterfall Behavior During Venous Pressure Elevation in Isolated Canine Hearts

• Published in: Circulation research Vol. 68; no. 2; pp. 392 - 401
• Main Authors: Farhi, Eli R, Klocke, Francis J, Mates, Robert E, Kumar, Krishna, Judd, Robert M, Canty, John M, Satoh, Shoichi, Sekovski, Blaze
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD American Heart Association, Inc 01.02.1991; Lippincott
• Subjects: Animals; Biological and medical sciences; Coronary Circulation; Differential Threshold; Dogs; Fundamental and applied biological sciences. Psychology; Hemodynamics. Rheology; In Vitro Techniques; Models, Cardiovascular; Muscle Tonus; Venous Pressure; Vertebrates: cardiovascular system; Heart; Fissipedia; Carnivora; Vertebrata; Vasomotricity; Mammalia; Blood pressure; Circulatory system; Hemodynamics; Dog; Blood flow
• ISSN: 0009-7330; 1524-4571
• DOI: 10.1161/01.res.68.2.392

We examined the “vascular waterfall” hypothesis, which proposes that coronary flow is unaffected by elevations in outflow pressure until the latter reaches a critical threshold level, in 29 isolated canine hearts. In fibrillating hearts vasodilated with adenosine or carbocromen, coronary flow and the coronary pressure-flow relation were not affected by changes in great cardiac vein pressure (PGCV) below a threshold value of 11±0.9 (mean±SEM) mm Hg. Further elevations of PGCV reduced flow and shifted the pressure-flow relation to the right, increasing its pressure-axis intercept (Pf=0). When vasomotor tone was augmented with vasopressin, threshold PGCV increased to 25±2.7 mm Hg (p<0.001). Once again, the pressure-flow relation was unaffected by changes in PGCV below the threshold value and shifted to the right when this value was exceeded. The amount by which spontaneous values of Pf=0 exceeded threshold values of PGCV was greater when vasomotor tone was augmented than during vasodilation. Pf=0 continued to exceed PGCV when the latter was raised above the threshold level. Both Pf=0 and threshold values of PGCV were less during a long diastole than during ventricular fibrillation. We reached the following conclusions. 1) During changes in PGCV below a threshold value, the coronary circulation exhibits traditional waterfall behavior. 2) The threshold pressure for altering waterfall behavior is affected by vascular tone and mechanical activity. 3) Pf=0 remains above PGCV when the latter is increased above the threshold value needed to alter flow. (Circulation Research 1991;68:392–401)