Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide-field, full-color imaging

In modern endoscopy, wide field of view and full color are considered necessary for navigating inside the body, inspecting tissue for disease and guiding interventions such as biopsy or surgery. Current flexible endoscope technologies suffer from reduced resolution when device diameter shrinks. Endo...

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Bibliographic Details
Published inJournal of biophotonics Vol. 3; no. 5-6; pp. 385 - 407
Main Authors Lee, Cameron M., Engelbrecht, Christoph J., Soper, Timothy D., Helmchen, Fritjof, Seibel, Eric J.
Format Journal Article
LanguageEnglish
Published Berlin WILEY-VCH Verlag 01.06.2010
WILEY‐VCH Verlag
Subjects
Animals
Catheterization
Color
Elasticity
endomicroscopy
Endoscopes
endoscopy
Humans
medical imaging
optical scanning
two-photon microscopy
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Summary:In modern endoscopy, wide field of view and full color are considered necessary for navigating inside the body, inspecting tissue for disease and guiding interventions such as biopsy or surgery. Current flexible endoscope technologies suffer from reduced resolution when device diameter shrinks. Endoscopic procedures today, using coherent fiber‐bundle technology on the scale of 1 mm, are performed with such poor image quality that the clinician's vision meets the criteria for legal blindness. Here, we review a new and versatile scanning fiber‐imaging technology and describe its implementation for ultrathin and flexible endoscopy. This scanning fiber endoscope (SFE) or catheterscope enables high‐quality, laser‐based, video imaging for ultrathin clinical applications, while also providing new options for in vivo biological research of subsurface tissue and high resolution fluorescence imaging. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Bibliography:NIH/NCI - No. R21 CA110184; No. R21/R33 CA094303
NCI - No. U54 CA136429; No. CA 128231
Human Frontier Science Program
istex:4A32D64F090572B6B8594175F3580574A9C01571
NIBIB - No. R01008119; No. RC1EB010900
Swiss National Center for Competence in Research 'Neural Plasticity and Repair'
EU-FP7 program - No. 200873
ark:/67375/WNG-8MMSF8TK-R
W. H. Coulter Foundation
NSF - No. CBET 0809070
The Whitaker Foundation
Washington Technology Center
ArticleID:JBIO200900087
PENTAX (HOYA Corporation)
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ObjectType-Feature-2
ISSN:1864-063X
1864-0648
1864-0648
DOI:10.1002/jbio.200900087