Jumonji domain‐containing protein 6 protein and its role in cancer

• Published in: Cell proliferation Vol. 53; no. 2; pp. e12747 - n/a
• Main Authors: Yang, Jing, Chen, Siyuan, Yang, Yanfei, Ma, Xuelei, Shao, Bin, Yang, Shengyong, Wei, Yuquan, Wei, Xiawei
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2020; John Wiley and Sons Inc
• Subjects: Adenosine triphosphate; Animals; Arginine; Binding sites; Cancer; Demethylation; Deoxyribonucleic acid; Diabetes mellitus; Diabetic neuropathy; Disease Progression; DNA; DNA methylation; Embryogenesis; Embryonic growth stage; Enzymes; Epigenetics; Gene expression; Hepatitis C; Histones; Humans; Hydroxylation; Immunological tolerance; Iron; JMJD6 protein; Jumonji Domain-Containing Histone Demethylases - metabolism; jumonji domain‐containing histone demethylases; Kinases; Localization; Lysine; Neoplasms - metabolism; Neoplasms - pathology; Oxygenase; Peptides; Protein-tyrosine kinase; Proteins; Review; Reviews; Tyrosine; JMJD6 protein; cancer; jumonji domain-containing histone demethylases; epigenetics
• ISSN: 0960-7722; 1365-2184
• DOI: 10.1111/cpr.12747

The jumonji domain‐containing protein 6 (JMJD6) is a Fe(II)‐ and 2‐oxoglutarate (2OG)‐dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non‐histone peptides. Recently, the intrinsic tyrosine kinase activity of JMJD6 has also been reported. The JMJD6 has been implicated in embryonic development, cellular proliferation and migration, self‐tolerance induction in the thymus, and adipocyte differentiation. Not surprisingly, abnormal expression of JMJD6 may contribute to the development of many diseases, such as neuropathic pain, foot‐and‐mouth disease, gestational diabetes mellitus, hepatitis C and various types of cancer. In the present review, we summarized the structure and functions of JMJD6, with particular emphasis on the role of JMJD6 in cancer progression.