Association between GPx‐1 polymorphisms and personality traits in healthy Chinese‐Han subjects

• Published in: Brain and behavior Vol. 10; no. 12; pp. e01897 - n/a
• Main Authors: Shao, Xiaojun, Sun, Dongxue, Zhang, Bihui, Cheng, Lingfei, Yan, Ci, Zhu, Gang
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.12.2020; John Wiley and Sons Inc; Wiley
• Subjects: Alzheimer's disease; Animal cognition; Antioxidants; Brain research; Cardiovascular disease; China; Chinese; Cognitive ability; Deoxyribonucleic acid; DNA; Dopamine; Enzymes; Female; gene polymorphism; Genotype; Glutathione; Glutathione Peroxidase - genetics; glutathione peroxidase 1; Glutathione Peroxidase GPX1; Humans; Impulsivity; Male; Mental disorders; Nervous system; Original Research; Oxidative stress; Parkinson's disease; Personality; Personality - genetics; personality trait; Personality traits; Polymorphism, Genetic; Questionnaires; Schizophrenia; Social research; China; Chinese; gene polymorphism; glutathione peroxidase 1; personality trait
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1897

Objectives Cloninger developed the three‐dimensional personality theory and Tridimensional Personality Questionnaire (TPQ), which shows that some dimensions of personality traits are heritable and related to neurotransmitters including dopamine. glutathione peroxidase 1 (GPx1) plays an important role in metabolic dopamine change and closely relates to neurological and psychiatric disorders. The impact of GPx‐1 polymorphisms has been rarely explored in the field of personality traits. We decide to explore the relationships between them in healthy Chinese‐Han subjects by using the polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP). Methods In our study, 493 healthy Chinese‐Han participants (male = 234, female = 259) were recruited. 2 ml of EDTA‐treated blood from each volunteer was taken; meanwhile, personality traits were assessed by TPQ. We detected the genotypes of selected two polymorphisms through PCR‐RFLP after extracting DNA. Finally, the association between different genotypes and TPQ scores was performed using SPSS, p < .05 is seen as significant statistical significance. Results Our data found a correlation between rs1800668 and novelty seeking (NS) subscale NS2 (X2 = 7.392, p = .025). While the results showed the rs1050450 was significantly associated with NS4 (X2 = 6.059, p = .048). Regarding sex stratification, there was a significant difference in the NS2 score (X2 = 8.232, p = .016) among women for rs1800668. No sex effect was observed for either genotype for rs1050450. Conclusion GPx‐1polymorphism is related to personality traits in healthy Chinese‐Han subjects. Our results suggested that GPx‐1 may be involved in the biological mechanisms and be a potential gene that influenced personality. This study is the first to thoroughly investigate associations between GPx‐1 polymorphisms and personality traits. Our results demonstrated that rs1050450 was significantly associated with the disorderliness trait. The rs1800668 polymorphism in GPx‐1 affected the personality trait of impulsiveness in healthy Chinese‐Han subjects.