Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

• Published in: Journal of cellular physiology Vol. 232; no. 12; pp. 3261 - 3272
• Main Authors: Chen, Tong, You, Yanan, Jiang, Hua, Wang, Zack Z.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2017
• Subjects: Animals; Biological activity; Cancer; cancer stem cells; Cell Differentiation; Cell Transformation, Neoplastic; Cellular Reprogramming; Differentiation (biology); Embryogenesis; Embryonic growth stage; EMT; Epithelial cells; Epithelial-Mesenchymal Transition; Epithelium; Humans; Mesenchyme; MET; Metastases; reprogramming; Stem cells; Stem Cells - cytology; Tumorigenesis; reprogramming; stem cells; cancer stem cells; EMT; MET

The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and dis...