Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and dis...

Full description

Saved in:
Bibliographic Details
Published inJournal of cellular physiology Vol. 232; no. 12; pp. 3261 - 3272
Main Authors Chen, Tong, You, Yanan, Jiang, Hua, Wang, Zack Z.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2017
Subjects
Animals
Biological activity
Cancer
cancer stem cells
Cell Differentiation
Cell Transformation, Neoplastic
Cellular Reprogramming
Differentiation (biology)
Embryogenesis
Embryonic growth stage
EMT
Epithelial cells
Epithelial-Mesenchymal Transition
Epithelium
Humans
Mesenchyme
MET
Metastases
reprogramming
Stem cells
Stem Cells - cytology
Tumorigenesis
reprogramming
stem cells
cancer stem cells
EMT
MET
Online AccessGet full text

Cover

More Information
Summary:The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and diseases, such as cancer invasion and metastasis. The EMT and the reverse process, mesenchymal–epithelial transition (MET), also play important roles in stem cell differentiation and de‐differentiation (or reprogramming). In this review, we will discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normal and in diseases. Understanding of EMT and MET may help to identify specific markers to distinguish normal stem cells from cancer stem cells in future. In this review, we discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normals and in diseases.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
T.C. and Y.Y. contributed equally to this work.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.25797