Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis

The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and dis...

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Published in	Journal of cellular physiology Vol. 232; no. 12; pp. 3261 - 3272
Main Authors	Chen, Tong, You, Yanan, Jiang, Hua, Wang, Zack Z.
Format	Journal Article
Language	English
Published	United States Wiley Subscription Services, Inc 01.12.2017
Subjects	Animals Biological activity Cancer cancer stem cells Cell Differentiation Cell Transformation, Neoplastic Cellular Reprogramming Differentiation (biology) Embryogenesis Embryonic growth stage EMT Epithelial cells Epithelial-Mesenchymal Transition Epithelium Humans Mesenchyme MET Metastases reprogramming Stem cells Stem Cells - cytology Tumorigenesis reprogramming stem cells cancer stem cells EMT MET
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Abstract	The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and diseases, such as cancer invasion and metastasis. The EMT and the reverse process, mesenchymal–epithelial transition (MET), also play important roles in stem cell differentiation and de‐differentiation (or reprogramming). In this review, we will discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normal and in diseases. Understanding of EMT and MET may help to identify specific markers to distinguish normal stem cells from cancer stem cells in future. In this review, we discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normals and in diseases.
AbstractList	The lineage transition between epithelium and mesenchyme is a process known as epithelial-mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and diseases, such as cancer invasion and metastasis. The EMT and the reverse process, mesenchymal-epithelial transition (MET), also play important roles in stem cell differentiation and de-differentiation (or reprogramming). In this review, we will discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normal and in diseases. Understanding of EMT and MET may help to identify specific markers to distinguish normal stem cells from cancer stem cells in future. The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their adhesion property and obtain mesenchymal cell phenotypes. EMT is a biological process that is often involved in embryogenesis and diseases, such as cancer invasion and metastasis. The EMT and the reverse process, mesenchymal–epithelial transition (MET), also play important roles in stem cell differentiation and de‐differentiation (or reprogramming). In this review, we will discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normal and in diseases. Understanding of EMT and MET may help to identify specific markers to distinguish normal stem cells from cancer stem cells in future. In this review, we discuss current research progress of EMT in embryonic development, cellular differentiation and reprogramming, and cancer progression, all of which are representative models for researches of stem cell biology in normals and in diseases.
Author	Wang, Zack Z. Chen, Tong You, Yanan Jiang, Hua
AuthorAffiliation	3 Johns Hopkins University School of Medicine, Division of Hematology, Baltimore, MD 21205, United States 1 Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China 2 Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai 200011, China
AuthorAffiliation_xml	– name: 2 Department of Gynecology, Obstetrics & Gynecology Hospital, Fudan University, Shanghai 200011, China – name: 1 Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, China – name: 3 Johns Hopkins University School of Medicine, Division of Hematology, Baltimore, MD 21205, United States
Author_xml	– sequence: 1 givenname: Tong surname: Chen fullname: Chen, Tong email: chentong@fudan.edu.cn organization: Fudan University – sequence: 2 givenname: Yanan surname: You fullname: You, Yanan organization: Fudan University – sequence: 3 givenname: Hua surname: Jiang fullname: Jiang, Hua organization: Fudan University – sequence: 4 givenname: Zack Z. orcidid: 0000-0002-6702-2648 surname: Wang fullname: Wang, Zack Z. email: zack.wang@jhmi.edu organization: Johns Hopkins University School of Medicine
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28079253$$D View this record in MEDLINE/PubMed
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Snippet	The lineage transition between epithelium and mesenchyme is a process known as epithelial–mesenchymal transition (EMT), by which polarized epithelial cells... The lineage transition between epithelium and mesenchyme is a process known as epithelial-mesenchymal transition (EMT), by which polarized epithelial cells...
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SubjectTerms	Animals Biological activity Cancer cancer stem cells Cell Differentiation Cell Transformation, Neoplastic Cellular Reprogramming Differentiation (biology) Embryogenesis Embryonic growth stage EMT Epithelial cells Epithelial-Mesenchymal Transition Epithelium Humans Mesenchyme MET Metastases reprogramming Stem cells Stem Cells - cytology Tumorigenesis
Title	Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis
URI	https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcp.25797 https://www.ncbi.nlm.nih.gov/pubmed/28079253 https://www.proquest.com/docview/1930913504 https://pubmed.ncbi.nlm.nih.gov/PMC5507753
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