Whole‐genome analysis reveals the hybrid formation of Chinese indigenous DHB pig following human migration

• Published in: Evolutionary applications Vol. 15; no. 3; pp. 501 - 514
• Main Authors: Wang, Yuzhan, Zhang, Chunyuan, Peng, Yebo, Cai, Xinyu, Hu, Xiaoxiang, Bosse, Mirte, Zhao, Yiqiang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.03.2022; John Wiley and Sons Inc; Wiley
• Subjects: Body weight; Breeding; DaHuaBai pig; Domestication; Gene frequency; Genes; Genomes; Genomics; Genotypes; Haplotypes; Hogs; human migration; Hybridization; Immigrants; Migration; Original; PCM1; Phenotypes; Sheep; two‐step introgression; China; DaHuaBai pig; body weight; human migration; PCM1; two‐step introgression; hybridization
• ISSN: 1752-4571; 1752-4571
• DOI: 10.1111/eva.13366

Hybridization is widespread in nature and is a valuable tool in domestic breeding. The DHB (DaHuaBai) pig in South China is the product of such a breeding strategy, resulting in increased body weight compared with other pigs in the surrounding area. We analyzed genomic data from 20 Chinese pig breeds and investigated the genomic architecture after breed formation of DHB. The breed showed inconsistency in genotype and body weight phenotype, in line with selection after hybridization. By quantifying introgression with a haplotype‐based approach, we proposed a two‐step introgression from large‐sized pigs into small‐sized pigs to produce DHB, consistent with the human migration events in Chinese history. Combining with gene prioritization and allele frequency analysis, we identify candidate genes that showed selection after introgression and that may affect body weight, such as IGF1R, SRC, and PCM1. Our research provides an example of a hybrid formation of domestic breeds along with human migration patterns.