Enhanced expression of cytokines/chemokines in cerebrospinal fluids in mumps meningitis in children

Background:  The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis‐specific cytok...

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Published inPediatrics international Vol. 53; no. 2; pp. 143 - 146
Main Authors Asano, Takeshi, Ichiki, Kunihiko, Koizumi, Shinya, Kaizu, Kiyohiko, Hatori, Takayuki, Fujino, Osamu, Mashiko, Kunihiro, Sakamoto, Yuichiro, Miyasho, Taku, Fukunaga, Yoshitaka
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Publishing Asia 01.04.2011
Blackwell Publishing Ltd
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Summary:Background:  The mumps virus is frequently the causative agent in aseptic meningitis and mumps has still prevailed in Japan. We compared data obtained from patients with mumps meningitis and patients with aseptic meningitis caused by other viruses in order to identify mumps meningitis‐specific cytokine/chemokine alterations in cerebrospinal fluide (CSF). Methods:  We elucidated the cytokine/chemokine network based on the cytokine/chemokine profiles in CSF from children with mumps meningitis and meningitis due to other viral infections using multiplex cytokine measurement. Seventeen cytokines/chemokines, namely interleukin (IL)‐1β, IL‐2, IL‐4, IL‐5, IL‐6, IL‐7, IL‐8, IL‐10, IL‐12 (p70), IL‐13, IL‐17, interferon (IFN)‐γ, tumor necrosis factor (TNF)‐α, granulocyte colony‐stimulating factor (G‐CSF), granulocyte monocyte colony‐stimulating factor (GM‐CSF), monocyte chemoattractant protein‐1 (MCP‐1) and macrophage inflammatory protein‐1β (MIP‐1β), were measured simultaneously in CSF supernatants from eight children with mumps meningitis, 11 children with other types of viral meningitis and eight children with fever without neurological complications such as convulsion. Results:  We found that IL‐8, IL‐10, IL‐12, IL‐13 and IFN‐γ showed a statistically significant increase in CSF from mumps meningitis when compared to other types of viral meningitis and fever without neurological complications. Conclusion:  Mumps meningitis may induce a distinct immunological response when compared with other types of viral meningitis.
Bibliography:istex:B87A4FA06E6E8B67CC6FBFF5A1A206DD1F4B2BC7
ArticleID:PED3215
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ISSN:1328-8067
1442-200X
DOI:10.1111/j.1442-200X.2010.03215.x