Initial therapeutic results of atezolizumab plus bevacizumab for unresectable advanced hepatocellular carcinoma and the importance of hepatic functional reserve

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 3; pp. 2646 - 2657
• Main Authors: Tomonari, Tetsu, Tani, Joji, Sato, Yasushi, Tanaka, Hironori, Tanaka, Takahiro, Taniguchi, Tatsuya, Asahiro, Morishita, Okamoto, Koichi, Sogabe, Masahiro, Miyamoto, Hiroshi, Muguruma, Naoki, Masaki, Tsutomu, Takayama, Tetsuji
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2023; John Wiley and Sons Inc; Wiley
• Subjects: Albumins; atezolizumab; Bevacizumab; Bilirubin; Cancer therapies; Carcinoma, Hepatocellular; Drug therapy; Hepatitis B; Hepatitis C; Hepatocellular carcinoma; Humans; Immunotherapy; Liver cancer; Liver Neoplasms; Monoclonal antibodies; Multivariate analysis; Patients; Response rates; Solid tumors; Targeted cancer therapy; Tumors; bevacizumab; atezolizumab; hepatocellular carcinoma
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.5145

Aim We analyzed the association between the modified albumin–bilirubin (mALBI) grade and therapeutic efficacy of atezolizumab plus bevacizumab (Atezo+Bev) for the treatment of unresectable hepatocellular carcinoma (u‐HCC). Methods In this retrospective observational study, we included 71 u‐HCC patients treated with Atezo+Bev between September 2020 and September 2021. Patients were grouped corresponding to the mALBI grade at the start of treatment (mALBI 1+2a or mALBI 2b+3) and analyzed for therapeutic effect and the transition rate to secondary treatment. Results According to the Response Evaluation Criteria in Solid Tumors, the overall response rate was significantly higher for the mALBI 1+2a group, than for the mALBI 2b+3 group, with 26.2% and 3.4%, respectively. The progression‐free survival (PFS) was significantly longer in the mALBI 1+2a group (10.5 months) than in the mALBI 2b+3 group (3.0 months). In the multivariate analysis, an mALBI of 1+2a was found to be an independent factor of PFS. The rate of second‐line treatment with multi‐targeted agents was also significantly higher in the mALBI 1+2a group. Conclusions In real‐world practice, Atezo+Bev treatment might have higher therapeutic efficacy in u‐HCC patients with mALBI 1+2a. Our data suggest that Atezo+Bev treatment has a good anti‐tumor effect on mALBI 1+2a and a reasonable transition rate to the subsequent molecular‐targeted agents treatment.